Neural correlates of word processing influenced by painful primes

• Published in: PloS one 2024-01, Vol.19 (1), p.e0295148-e0295148
• Main Authors: Brodhun, Christoph, Borelli, Eleonora, Weiss, Thomas
• Format: Article
• Language: English
• Subjects: Amplitudes; Analysis; Computational linguistics; Electrical stimuli; Electrodes; Electroencephalography; Event-related potentials; Evoked potentials (Electrophysiology); Evoked Potentials - physiology; Experiments; Female; Humans; Information processing; Language processing; Male; Methods; Natural language interfaces; Neurophysiology; Pain; Reaction Time - physiology; Schiller, Johann Christoph Friedrich von (1759-1805); Semantics; Stimulation; Word Processing
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0295148

The administration of painful primes has been shown to influence the perception of successively presented semantic stimuli. Painful primes lead to more negative valence ratings of pain-related, negative, and positive words than no prime. This effect was greater for pain-related than negative words. The identities of this effect's neural correlates remain unknown. In this EEG experiment, 48 healthy subjects received noxious electrical stimuli of moderate intensity. During this priming, they were presented with adjectives of variable valence (pain-related, negative, positive, and neutral). The triggered event-related potentials were analyzed during N1 (120-180 ms), P2 (170-260 ms), P3 (300-350 ms), N400 (370-550 ms), and two late positive complex components (LPC1 [650-750 ms] and LPC2 [750-1000 ms]). Larger event-related potentials were found for negative and pain-related words compared to positive words in later components (N400, LPC1, and LPC2), mainly in the frontal regions. Early components (N1, P2) were less affected by the word category but were by the prime condition (N1 amplitude was smaller with than without painful stimulation, P2 amplitude was larger with than without painful stimulation). Later components (LPC1, LPC2) were not affected by the prime condition. An interaction effect involving prime and word category was found on the behavioral level but not the electrophysiological level. This finding indicates that the interaction effect does not directly translate from the behavioral to the electrophysiological level. Possible reasons for this discrepancy are discussed.