Association of Kawasaki disease with urbanization level and family characteristics in Taiwan: A nested case-control study using national-level data

Kawasaki disease (KD) is an inflammatory vasculitis disorder of unknown etiology. It is a rare but fatal disease and the leading cause of acquired coronary heart disease in children under the age of 5 years. We examined the association of KD with the demographics of family members, parents' cha...

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Bibliographic Details
Published in:PloS one 2024-01, Vol.19 (1), p.e0296505-e0296505
Main Authors: Tseng, Chung-Fang, Lin, Hsiao-Chen, Tzeng, Chung-Yuh, Huang, Jing-Yang, Yeh, Chih-Jung, Wei, James Cheng-Chung
Format: Article
Language:English
Subjects:
Age
Apgar score
Autoimmune diseases
Birth weight
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Case studies
Children
Children & youth
Chronic obstructive pulmonary disease
Codes
Coronary artery disease
Coronary heart disease
Data analysis
Data science
Demographics
Development and progression
Diagnosis
Diseases
Domestic relations
Families & family life
Family
Gestational age
Gestational diabetes
Health aspects
Heart diseases
Hospitals
Hypertension
Inflammatory diseases
Kawasaki disease
Mothers
Mucocutaneous lymph node syndrome
Multiple births
Parenting
Parents
Parents & parenting
Pediatric cardiology
Preeclampsia
Risk
Scandals
Siblings
Socioeconomic factors
Socioeconomic status
Socioeconomics
Statistical analysis
Urban areas
Urbanization
Vasculitis
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Summary:Kawasaki disease (KD) is an inflammatory vasculitis disorder of unknown etiology. It is a rare but fatal disease and the leading cause of acquired coronary heart disease in children under the age of 5 years. We examined the association of KD with the demographics of family members, parents' characteristics, and perinatal factors in Taiwanese children. This nested case-control study used data from Taiwan's Health and Welfare Data Science Center and initially included children born in Taiwan between January 1, 2006, and December 31, 2015 (n = 1,939,449); the children were observed for KD development before the age of 5 years (n = 7870). The control group consisted of children without KD who were matched with each KD case by sex and birth date at a ratio of 8:1. The odds ratio (ORs) of the aforementioned associations were estimated using conditional logistic regression. The risk of KD decreased in children with younger parents [
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0296505