High-sensitivity analysis of clonal hematopoiesis reveals increased clonal complexity of potential-driver mutations in severe COVID-19 patients

Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains a controversial issue. We report the first high- sensitivity analysis of CH in COVID-19 patients (threshold of detection at 0.5% vs 1 or 2% in previous studies). We analyzed 24 patients admitted t...

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Published in:PloS one 2024-01, Vol.19 (1), p.e0282546-e0282546
Main Authors: Ronchini, Chiara, Caprioli, Chiara, Tunzi, Gianleo, D'Amico, Francesco Furio, Colombo, Emanuela, Giani, Marco, Foti, Giuseppe, Conconi, Donatella, Lavitrano, Marialuisa, Passerini, Rita, Pase, Luca, Capizzi, Silvio, Mastrilli, Fabrizio, Alcalay, Myriam, Orecchia, Roberto, Natoli, Gioacchino, Pelicci, Pier Giuseppe
Format: Article
Language:English
Subjects:
Analysis
Asymptomatic
Biology and Life Sciences
Cloning
Complexity
COVID-19
COVID-19 vaccines
Diagnosis
Disease
Gene frequency
Gene mutations
Genes
Genetic aspects
Genomics
Health aspects
Hematopoiesis
Hemopoiesis
Hospital patients
Hospitalization
Immunization
Infections
Inflammation
Medical research
Medicine and Health Sciences
Medicine, Experimental
Mutation
Neoplasms
Pandemics
Peripheral blood
Research and Analysis Methods
Risk factors
Sensitivity analysis
Severe acute respiratory syndrome coronavirus 2
Software
Statistical analysis
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Summary:Whether Clonal Hematopoiesis (CH) represents a risk factor for severity of the COVID-19 disease remains a controversial issue. We report the first high- sensitivity analysis of CH in COVID-19 patients (threshold of detection at 0.5% vs 1 or 2% in previous studies). We analyzed 24 patients admitted to ICU for COVID-19 (COV-ICU) and 19 controls, including healthy subjects and asymptomatic SARS-CoV2-positive individuals. Despite the significantly higher numbers of CH mutations identified (80% mutations with
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0282546