Systematic review and meta-analysis: Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes

Intrahepatic cholestasis of pregnancy (ICP) is a serious liver conditions that negatively impacts obstetric and neonatal outcomes. Elevated levels of bile acid, particularly glycine conjugate, may compromise blood flow and cause functional hypoxia-ischemia. This meta-analysis aims to assess the asso...

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Bibliographic Details
Published in:PloS one 2024-06, Vol.19 (6), p.e0304604
Main Authors: Huang, Xuexia, Gu, Huifeng, Shen, Pinghua, Zhang, Xiaoxing, Fei, Anping
Format: Article
Language:English
Subjects:
Acids
Age
Analysis
Bibliographic literature
Bile
Bile acids
Biology and Life Sciences
Births
Blood flow
Cesarean Section
Childbirth & labor
Cholestasis
Cholestasis, Intrahepatic - complications
Cholestasis, Intrahepatic - epidemiology
Cohort analysis
Data analysis
Female
Fetuses
Gallbladder diseases
Gestational Age
Glycine
Hemorrhage
Humans
Hypoxia
Infant, Newborn
Infant, Small for Gestational Age
Infants (Premature)
Ischemia
Jaundice, Obstructive
Liver
Medicine and Health Sciences
Meta-analysis
Neonatal intensive care
Neonates
Newborn babies
Obstetrics
Physical Sciences
Pre-eclampsia
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
Pregnancy complications
Pregnancy Complications - epidemiology
Pregnancy Outcome
Pregnant women
Premature birth
Premature Birth - epidemiology
Research and Analysis Methods
Small for gestational age
Stillbirth
Stillbirth - epidemiology
Systematic review
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Summary:Intrahepatic cholestasis of pregnancy (ICP) is a serious liver conditions that negatively impacts obstetric and neonatal outcomes. Elevated levels of bile acid, particularly glycine conjugate, may compromise blood flow and cause functional hypoxia-ischemia. This meta-analysis aims to assess the association between ICP and key pregnancy outcomes including emergency caesarian sections (C-sections), preeclampsia, hemorrhage, preterm birth, small for gestational age, admission rate to neonatal intensive care union (NICU), gestational age, and stillbirth. Literature search across five databases (PubMed, Embase, Web of Science) was done to detect relevant studies published up until June 2023. Meta-analysis of the identified studies was done using a random-effects model, and the results presented as Odds ratio (OR). A literature search identified 662 studies. Of them, 21 met the inclusion criteria. There was a significant association between ICP and odds of C-section (OR: 1.42, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0304604