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Prevalence and factors associated with celiac disease in high-risk patients with functional gastrointestinal disorders

Celiac disease (CD) is an autoimmune disease of the small intestine triggered by the consumption of gluten-containing foods in individuals with a genetic predisposition. CD was a rare disease until 20 years ago, when the prevalence increased. Currently, there is no data on the prevalence of CD in hi...

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Published in:PloS one 2024-06, Vol.19 (6), p.e0297605
Main Authors: Syam, Ari Fahrial, Utari, Amanda Pitarini, Hasanah, Nur Hamidah, Rizky, Almaarif, Abdullah, Murdani
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Abdullah, Murdani
description Celiac disease (CD) is an autoimmune disease of the small intestine triggered by the consumption of gluten-containing foods in individuals with a genetic predisposition. CD was a rare disease until 20 years ago, when the prevalence increased. Currently, there is no data on the prevalence of CD in high-risk adult populations in Indonesia, even though there is a trend of increasing gluten consumption. Therefore, basic research is needed to determine the magnitude of CD in high-risk adult patients in Indonesia while identifying clinical signs/symptoms, illness history, and lifestyle to determine factors associated with CD in Indonesia. This study is an observational study with a cross-sectional method.Two hundred eighty-three patients who fulfilled the selection and signed the informed consent were recruited from the gastroenterology clinic of Dr. Cipto Mangunkusumo General Hospital. Patients were asked to fill out a celiac disease-related questionnaire and then given anthropometry measurement and blood test for serologic examination with ELISA, consisting of IgA anti-tissue transglutaminase (anti-TTG) and IgG anti-deaminated gliadin peptide (anti-DGP). Statistical analysis was performed using Chi-square and Multivariate logistic regression tests with SPSS software ver. 26. Statistical test differences were considered significant if the p-values were < 0.05. Eight of 283 patients are serologically confirmed with CD (2,83%). On bivariate analysis, the significant variables are age (p < 0,05), constipation (p < 0,05) and history of autoimmune disease (p < 0,05). On multivariate analysis, the only significant variable is the history of autoimmune disease (p < 0,05). This study concluded that the prevalence of CD in high-risk patients with functional gastrointestinal disorder at Dr. Cipto Mangunkusumo Hospital is relatively high (2.83%). CD-associated factors are age, constipation, and history of autoimmune disease in patients. On simultaneous interaction between these factors, autoimmune is the only significant variable associated with CD.
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CD was a rare disease until 20 years ago, when the prevalence increased. Currently, there is no data on the prevalence of CD in high-risk adult populations in Indonesia, even though there is a trend of increasing gluten consumption. Therefore, basic research is needed to determine the magnitude of CD in high-risk adult patients in Indonesia while identifying clinical signs/symptoms, illness history, and lifestyle to determine factors associated with CD in Indonesia. This study is an observational study with a cross-sectional method.Two hundred eighty-three patients who fulfilled the selection and signed the informed consent were recruited from the gastroenterology clinic of Dr. Cipto Mangunkusumo General Hospital. Patients were asked to fill out a celiac disease-related questionnaire and then given anthropometry measurement and blood test for serologic examination with ELISA, consisting of IgA anti-tissue transglutaminase (anti-TTG) and IgG anti-deaminated gliadin peptide (anti-DGP). Statistical analysis was performed using Chi-square and Multivariate logistic regression tests with SPSS software ver. 26. Statistical test differences were considered significant if the p-values were &lt; 0.05. Eight of 283 patients are serologically confirmed with CD (2,83%). On bivariate analysis, the significant variables are age (p &lt; 0,05), constipation (p &lt; 0,05) and history of autoimmune disease (p &lt; 0,05). On multivariate analysis, the only significant variable is the history of autoimmune disease (p &lt; 0,05). This study concluded that the prevalence of CD in high-risk patients with functional gastrointestinal disorder at Dr. Cipto Mangunkusumo Hospital is relatively high (2.83%). CD-associated factors are age, constipation, and history of autoimmune disease in patients. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Syam, Ari Fahrial</au><au>Utari, Amanda Pitarini</au><au>Hasanah, Nur Hamidah</au><au>Rizky, Almaarif</au><au>Abdullah, Murdani</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and factors associated with celiac disease in high-risk patients with functional gastrointestinal disorders</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2024-06-07</date><risdate>2024</risdate><volume>19</volume><issue>6</issue><spage>e0297605</spage><pages>e0297605-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Celiac disease (CD) is an autoimmune disease of the small intestine triggered by the consumption of gluten-containing foods in individuals with a genetic predisposition. CD was a rare disease until 20 years ago, when the prevalence increased. Currently, there is no data on the prevalence of CD in high-risk adult populations in Indonesia, even though there is a trend of increasing gluten consumption. Therefore, basic research is needed to determine the magnitude of CD in high-risk adult patients in Indonesia while identifying clinical signs/symptoms, illness history, and lifestyle to determine factors associated with CD in Indonesia. This study is an observational study with a cross-sectional method.Two hundred eighty-three patients who fulfilled the selection and signed the informed consent were recruited from the gastroenterology clinic of Dr. Cipto Mangunkusumo General Hospital. Patients were asked to fill out a celiac disease-related questionnaire and then given anthropometry measurement and blood test for serologic examination with ELISA, consisting of IgA anti-tissue transglutaminase (anti-TTG) and IgG anti-deaminated gliadin peptide (anti-DGP). Statistical analysis was performed using Chi-square and Multivariate logistic regression tests with SPSS software ver. 26. Statistical test differences were considered significant if the p-values were &lt; 0.05. Eight of 283 patients are serologically confirmed with CD (2,83%). On bivariate analysis, the significant variables are age (p &lt; 0,05), constipation (p &lt; 0,05) and history of autoimmune disease (p &lt; 0,05). On multivariate analysis, the only significant variable is the history of autoimmune disease (p &lt; 0,05). This study concluded that the prevalence of CD in high-risk patients with functional gastrointestinal disorder at Dr. Cipto Mangunkusumo Hospital is relatively high (2.83%). CD-associated factors are age, constipation, and history of autoimmune disease in patients. On simultaneous interaction between these factors, autoimmune is the only significant variable associated with CD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>38848393</pmid><doi>10.1371/journal.pone.0297605</doi><tpages>e0297605</tpages><orcidid>https://orcid.org/0000-0003-0041-3553</orcidid><oa>free_for_read</oa></addata></record>
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subjects Abdomen
Adolescent
Adult
Aged
Anemia
Anthropometry
Autoimmune diseases
Biology and Life Sciences
Bivariate analysis
Blood
Celiac disease
Celiac Disease - complications
Celiac Disease - epidemiology
Chi-square test
Constipation
Cross-Sectional Studies
Defecation
Development and progression
Diabetes
Diarrhea
Female
Food consumption
Gastroenterology
Gastrointestinal diseases
Gastrointestinal Diseases - epidemiology
Gluten
Hospitals
Humans
Immunoglobulin A
Immunoglobulin G
Indonesia - epidemiology
Informed consent
Intestine
Irritable bowel syndrome
Male
Medical examination
Medicine and Health Sciences
Menstruation
Middle Aged
Multivariate analysis
Nausea
Observational studies
Pain
Patients
People and Places
Peptides
Prevalence
Prevalence studies (Epidemiology)
Protein Glutamine gamma Glutamyltransferase 2
Questionnaires
Risk
Risk Factors
Risk groups
Signs and symptoms
Small intestine
Software testing
Statistical analysis
Statistical tests
Statistics
Thyroid diseases
Transglutaminase 2
Transglutaminases - immunology
Vomiting
Young Adult
title Prevalence and factors associated with celiac disease in high-risk patients with functional gastrointestinal disorders
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