Efficacy and safety of vitamin D supplementation on psoriasis: A systematic review and meta-analysis

Our aim was to analyze the results of published randomized controlled trials (RCTs) on vitamin D supplementation for psoriasis in order to explore its effectiveness and safety. As of July 7 2023, we conducted a systematic literature search in PubMed, Cochrane, Embase, and Web of Science Core Collect...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-11, Vol.18 (11), p.e0294239-e0294239
Main Authors: Dai, Qianqian, Zhang, Yanfeng, Liu, Qian, Zhang, Chijin
Format: Article
Language:English
Subjects:
Alfacalcidol
Analysis
Bias
Body mass index
C-reactive protein
Calcifediol
Calciferol
Care and treatment
Clinical trials
Dermatologic agents
Dermatology
Diagnosis
Dietary supplements
Effectiveness
Formulae, receipts, prescriptions
Health aspects
Homeostasis
Medical research
Medicine, Experimental
Meta-analysis
Patients
Psoriasis
Quality of life
Safety
Sensitivity analysis
Skin
Skin diseases
Statistical analysis
Statistical tests
Subgroups
Vitamin D
Vitamin D2
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Our aim was to analyze the results of published randomized controlled trials (RCTs) on vitamin D supplementation for psoriasis in order to explore its effectiveness and safety. As of July 7 2023, we conducted a systematic literature search in PubMed, Cochrane, Embase, and Web of Science Core Collection databases. The study outcomes included change values in Psoriasis Area and Severity Index (PASI) (at 3 months, 6 months, and end of follow-up)/Dermatology Life Quality Index (DLQI)/Psoriasis disability index (PDI)/C-reactive protein (CRP), and adverse events. 333 patients from 4 studies were evaluated. Pooled analyses showed no significant effect of DLQI/PDI/CRP change value (P > 0.05) or PASI change value (3 months, end of follow-up; P > 0.05). Sensitivity analyses and statistical tests did not support the results of the PASI change values (6 months, P = 0.05). However, the results of subgroup analyses should not be ignored(supplementation with vitamin D2 or Asia would be more effective; P = 0.03). There were no serious adverse effects, and only a few individuals experienced nausea. The efficacy and safety of vitamin D supplementation in the treatment of psoriasis remains unremarkable. The search for a new prognostic index that combines clinical and laboratory factors is needed to compensate for the shortcomings of existing measures and provide stronger evidence of validity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0294239