Determinants of participation in glaucoma genomic research in South East Nigeria: A cross-sectional analytical study

Genomic research advances the understanding of human health and disease. It also drives both the discovery of salient genetic association(s) as well as targeted screening, diagnostic and therapeutic strategies. Human subject participation is crucial for the success of genomic research. This is a cro...

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Bibliographic Details
Published in:PloS one 2023-11, Vol.18 (11), p.e0289643-e0289643
Main Authors: Uche, Nkechinyere J, Okoye, Onochie, Kizor-Akaraiwe, Nkiru, Chuka-Okosa, Chimdi, Uche, Enoch O
Format: Article
Language:English
Subjects:
Analysis
Chi-square test
Consent
Cross-Sectional Studies
Demographics
Education
Employment
Families & family life
Family medical history
Feedback
Female
Gender
Genealogy
Genetic research
Genomics
Glaucoma
Glaucoma - genetics
Health aspects
Humans
Logit models
Male
Marital status
Middle Aged
Missing data
Nigeria
Participation
Questionnaires
Sample size
Sociodemographics
Surveys
Surveys and Questionnaires
Teaching hospitals
Variables
Citations: Items that this one cites
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Summary:Genomic research advances the understanding of human health and disease. It also drives both the discovery of salient genetic association(s) as well as targeted screening, diagnostic and therapeutic strategies. Human subject participation is crucial for the success of genomic research. This is a cross sectional analytical study conducted at two tertiary centers in Enugu Southeast Nigeria. Semi structured questionnaires were administered to eligible consenting participants. Data on their demographics, willingness to participate in genomic research and motivation for participation were obtained. Data was analyzed using Stata version 17 and summarized using median, frequencies and interquartile range(IQR). Associations between covariates were evaluated with Chi square test and multivariable logistic regression. Among 228 glaucoma subjects who participated in our study,119(52.2%) were female and 109(47.8%) were male. The median age was 64 years(IQR = 50-76). Although 219 (96.0%) participants expressed willingness to participate in a glaucoma genetic study, only 27(11.9%) of them will be willing to participate if there will not be feedback of results to participants (χ2 = 18.59, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0289643