Diagnostic potential of serum HSP90 beta for HNSCC and its therapeutic prognosis after local hyperthermia therapy

The present pilot study aims to investigate the diagnostic and prognostic efficacy of serum HSP90 beta in Head and Neck Squamous Cell Carcinoma (HNSCC) patients subjected to localized hyperthermia therapy (HT). Serum levels of HSP90 beta were measured by ELISA and its diagnostic and prognostic effic...

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Bibliographic Details
Published in:PloS one 2023-11, Vol.18 (11), p.e0281919-e0281919
Main Authors: Shetake, Neena G, Kumar, Amit, Huilgol, Nagraj, Pandey, Badri N
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Comparative analysis
Cooling
Diagnosis
Diagnostic systems
Effectiveness
Enzyme-linked immunosorbent assay
Ethics
Fever
Gastric cancer
Head & neck cancer
Head and neck cancer
Head and neck carcinoma
Health aspects
Heat shock proteins
Hsp90 protein
Hyperthermia
Liver cancer
Medical diagnosis
Medical prognosis
Medicine and Health Sciences
Methods
Prognosis
Radiation therapy
Radiotherapy
Serum levels
Squamous cell carcinoma
Statistical analysis
Thermotherapy
Tumors
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Summary:The present pilot study aims to investigate the diagnostic and prognostic efficacy of serum HSP90 beta in Head and Neck Squamous Cell Carcinoma (HNSCC) patients subjected to localized hyperthermia therapy (HT). Serum levels of HSP90 beta were measured by ELISA and its diagnostic and prognostic efficacy was determined by receiver operating characteristic curve (ROC) analysis. HNSCC patients showed significantly (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0281919