Cost-effectiveness and cost-utility analyses of three different gargles in the treatment of chronic periodontitis

• Published in: PloS one 2024-05, Vol.19 (5), p.e0302592-e0302592
• Main Authors: Chen, Xin, Niu, Wenzhi, Hu, Guangyu, Chen, Changfeng
• Format: Article
• Language: English
• Subjects: Adult; Analysis; Bacteria; Biology and Life Sciences; Care and treatment; Chlorhexidine; Chlorhexidine - economics; Chlorhexidine - therapeutic use; Chronic Periodontitis - drug therapy; Chronic Periodontitis - economics; Chronic Periodontitis - therapy; Clinical medicine; Cost analysis; Cost benefit analysis; Dental plaque; Diabetes; Diagnosis; Drugs; Economic analysis; Economic aspects; Effectiveness; Evaluation; Female; Females; GDP; Gross Domestic Product; Gum disease; Health aspects; Hospitals; Humans; Male; Medicine and Health Sciences; Metronidazole; Middle Aged; Mouthwashes; Oral diseases; Oral hygiene; Patients; Periodontics; Periodontitis; Prices and rates; Quality of Life; Quality-Adjusted Life Years; Smoking; Social Sciences; Statistical analysis; Surveys and Questionnaires; Teeth
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0302592

This study aimed to investigate the economics of three different gargles in the treatment of chronic periodontitis. A total of 108 patients with periodontitis received one of the following three gargles: xipayi, compound chlorhexidine, or Kangfuxin gargle. The basic information of the patients, the costs of the gargles, the periodontal indexes before and after treatment, and the scores of the 3-level version of the EuroQol Five Dimensions Questionnaire were collected. The cost-effectiveness and cost-utility of the various gargles were determined. The cost-effectiveness ratios (CER) of the three groups after treatment were 1828.75, 1573.34, and 1876.92 RMB, respectively. The utility values before treatment were 0.92, 0.90, and 0.91, respectively, and the utility values after treatment were 0.98, 0.98, and 0.97, respectively. The cost-utility ratios (CURs) were 213.43, 195.61, and 301.53 RMB, respectively. For each increase in effective rate and quality-adjusted life years, the treatment cost of periodontitis patients was lower than the gross domestic product per capita of Jiangsu Province, indicating that the treatment cost is completely worth it. The CER and CUR results were the same, and the compound chlorhexidine group was the lowest, demonstrating that when the same therapeutic effect was achieved, it cost the least.