Study of correlations between serum taurine, thyroid hormones and echocardiographic parameters of systolic function in clinically healthy Golden retrievers fed with commercial diet

• Published in: PloS one 2024-05, Vol.19 (5), p.e0297811
• Main Authors: Bagardi, Mara, Ghilardi, Sara, Minozzi, Giulietta, Fusi, Eleonora, Locatelli, Chiara, Ferrari, Paolo Luigi, Drago, Giulia, Polli, Michele, Lorenzi, Elisa, Zanchi, Francesca, Brambilla, Paola Giuseppina
• Format: Article
• Language: English
• Subjects: Animal Feed - analysis; Animals; Automation; Biology and Life Sciences; Blood tests; Cardiomyopathy; Chromatography; Correlation; Cross-Sectional Studies; Diet; Diet - veterinary; Dilated cardiomyopathy; Disease; Dogs; Doppler effect; Echocardiography; Female; Heart; Hormones; Immunoassay; Laboratories; Legumes; Male; Medicine and Health Sciences; Nutrient deficiency; Parameters; Systole; Taurine; Taurine - blood; Teaching hospitals; Thyroid; Thyroid gland; Thyroid hormones; Thyroid Hormones - blood; Thyroxine; Ventricle
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0297811

Taurine deficiency predisposes to the development of nutritional dilated cardiomyopathy and is widespread in dogs fed with non-traditional diets. However, Golden retrievers show lower plasma taurine concentration and an impaired systolic function compared to breeds of the same size and morphotype. For these reasons, it can be difficult to classify a subject from a cardiological point of view, with the risk of considering as pathological characteristics that can be completely normal in this breed. This is a cross-sectional multicenter study. The aims were 1) to identify breed-specific range of serum taurine concentration, 2) to describe a correlation between serum taurine concentration and echocardiographic parameters of systolic function in clinically healthy Golden retrievers fed with traditional diet, 3) to identify a correlation between thyroid hormones, serum taurine concentration and echocardiographic indices. Sixty clinically healthy Golden retrievers (33% males, 67% females) were included. Fifty-three dogs were fed with traditional diets and their range of serum taurine concentration was 398.2 (31.8-430) nmol/ml. Serum taurine concentration was found to be negatively correlated to systolic internal diameter of the left ventricle and systolic and diastolic left ventricular indices and volumes obtained with different methods, whereas was positively correlated to the left ventricle ejection and shortening fractions but difference was not statistically significative. A weak but significant correlation between serum taurine and T4 was demonstrated. Serum taurine median values in dogs with normal systolic function were higher than in dogs with impaired systolic function. A cut-off of serum taurine concentration of 140.6 nmol/ml had a moderate sensitivity and specificity in the identification of an impaired left ventricular systolic function (AUC 0.6, Se 78%, Sp 44%). This study showed that the median serum taurine concentration was significantly lower in dogs with impaired systolic function. Therefore, echocardiographic monitoring is recommended in all dogs with serum taurine concentration lower than 140.6 nmol/ml.