Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007-2018

• Published in: PloS one 2024-05, Vol.19 (5), p.e0302410-e0302410
• Main Authors: Zeng, Xia, Huang, Jitian, Shen, Tianran, Xu, Yingxia, Yan, Xiaofang, Li, Qian, Li, Yanmei, Xing, Xiaohui, Chen, Qingsong, Yang, Wenhan
• Format: Article
• Language: English
• Subjects: Adult; Adults; Aged; Analysis; Biology and Life Sciences; Body mass index; Cardiovascular disease; Confidence intervals; Education; Ethnicity; Exercise; Female; Gout; Health surveys; Humans; Hyperuricemia; Hyperuricemia - epidemiology; Male; Medical laboratories; Medical personnel; Medicine and Health Sciences; Metabolism; Middle Aged; Nonlinear response; Nutrition Surveys; Physical activity; Physical fitness; Physical Sciences; Population; Questionnaires; Regression analysis; Review boards; Rheumatism; Risk; Secondary schools; Self report; Social Sciences; Spline functions; Statistical analysis; Surveys; United States - epidemiology; Uric acid; Uric Acid - blood; Variables
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0302410

The relationship between physical activity and hyperuricemia (HUA) remains inconsistent, and the dose-response association between moderate-to- vigorous physical activity (MVPA) level and HUA still unclear. In this study, we aimed to investigate the dose-response association of MVPA with HUA, and to explore an appropriate range of MVPA level for preventing HUA. Data from the US National Health and Nutrition Examination Survey (NHANES) 2007-2018 were used, including 28740 non-gout adult Americans. MVPA level was self-reported using the Global Physical Activity Questionnaire and serum uric acid was measured using timed endpoint method. The dose-response relationship between MVPA level and HUA was modeled with restricted cubic spline analysis. Logistic regression analysis were applied to estimate odd ratios (ORs) and 95% confidence intervals (CIs) of the relationships between MVPA level and HUA. A total of 28740 adults were included in the study (weighted mean age, 47.3 years; 46.5% men), with a prevalence rate of HUA was 17.6%. The restricted cubic spline functions depicted a general U-shaped relationship between MVPA level and HUA. The MVPA level of 933 and 3423 metabolic equivalent (MET) -min/wk were the cut-off discriminating for the risk of HUA. Participants with MVPA levels in the range of 933-3423 MET-min/wk had lower risk of HUA and they had the lowest risk when MVPA levels at around 1556 MET-min/wk. Compared with the moderate-activity group (600-2999 Met-min/wk), the low-activity group (< 600 Met-min/wk) had a greater risk of HUA (OR, 1.13 [95%CI, 1.02-1.26]) after fully adjusting for potential confounders. Compared with the moderate MVPA level, the low MVPA level was associated with the higher risk of HUA. And there may be a U-shaped dose-response relationship between MVPA level and HUA. When MVPA level was approximately 933-3423 MET-min/wk, the risk of HUA may at a lower level and the risk reached the lowest when MVPA level at around 1556 MET-min/wk.