A comparison of white matter microstructure and correlates with neuropsychological measures in younger and older adults

With a globally aging population, there is a need to better understand how brain structure relates to function in healthy older and younger adults. 34 healthy participants divided into older (17; Mean = 70.9, SD = 5.4) and younger adults (17; Mean = 28.1, SD = 2.8) underwent diffusion-weighted imagi...

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Published in:PloS one 2024-06, Vol.19 (6), p.e0305818
Main Authors: Sheriff, Abu-Bakar, Scarapicchia, Vanessa, Mazerolle, Erin L, Christie, Brian, Gawryluk, Jodie R
Format: Article
Language:English
Subjects:
Adult
Adults
Age
Aged
Aged, 80 and over
Aging
Aging - physiology
Anisotropy
Biology and Life Sciences
Brain
Brain - diagnostic imaging
Brain - physiology
Brain research
Cognition - physiology
Cognitive ability
Corona
Corpus callosum
Demographics
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging - methods
Education
Executive function
Executive Function - physiology
Female
Functional anatomy
Humans
Life span
Longitudinal studies
Magnetic resonance imaging
Male
Medicine and Health Sciences
Memory
Microstructure
Middle Aged
Neuroimaging
Neuropsychological Tests
Neuropsychology
Older people
People and Places
Physical Sciences
Research and Analysis Methods
Social Sciences
Structure-function relationships
Substantia alba
White Matter - diagnostic imaging
White Matter - physiology
Young Adult
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Scarapicchia, Vanessa
Mazerolle, Erin L
Christie, Brian
Gawryluk, Jodie R
description With a globally aging population, there is a need to better understand how brain structure relates to function in healthy older and younger adults. 34 healthy participants divided into older (17; Mean = 70.9, SD = 5.4) and younger adults (17; Mean = 28.1, SD = 2.8) underwent diffusion-weighted imaging and neuropsychological assessment, including the California Verbal Learning Test 2nd Edition and the Trail Making Test (TMT-A and TMT-B). Differences in white matter microstructure for older and younger adults and the association between DTI metrics (fractional anisotropy, FA; mean diffusivity, MD) and cognitive performance were analyzed using tract-based spatial statistics (p < 0.05, corrected). Older adults had significantly lower FA and higher MD than younger adults in widespread brain regions. There was a significant negative correlation between executive function (TMT-B) and MD for older adults in the right superior/anterior corona radiata and the corpus callosum. No significant relationship was detected between DTI metrics and executive function in younger adults or with memory performance in either group. The findings underscore the need to examine brain-behaviour relationships as a function of age. Future studies should include comprehensive assessments in larger lifespan samples to better understand the aging brain.
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subjects Adult
Adults
Age
Aged
Aged, 80 and over
Aging
Aging - physiology
Anisotropy
Biology and Life Sciences
Brain
Brain - diagnostic imaging
Brain - physiology
Brain research
Cognition - physiology
Cognitive ability
Corona
Corpus callosum
Demographics
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging - methods
Education
Executive function
Executive Function - physiology
Female
Functional anatomy
Humans
Life span
Longitudinal studies
Magnetic resonance imaging
Male
Medicine and Health Sciences
Memory
Microstructure
Middle Aged
Neuroimaging
Neuropsychological Tests
Neuropsychology
Older people
People and Places
Physical Sciences
Research and Analysis Methods
Social Sciences
Structure-function relationships
Substantia alba
White Matter - diagnostic imaging
White Matter - physiology
Young Adult
title A comparison of white matter microstructure and correlates with neuropsychological measures in younger and older adults
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