Identification of antibiotic induced persister cells in Streptococcus agalactiae

Antibiotic persistence is a phenomenon, where a small fraction of a bacterial population expresses a phenotypic variation that allows them to survive antibiotic treatment, which is lethal to the rest of the population. These cells are called persisters cells, and their occurrence has been associated...

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Bibliographic Details
Published in:PloS one 2024-06, Vol.19 (6), p.e0303271
Main Authors: Greve, Nanna Boll, Slotved, Hans-Christian, Olsen, John Elmerdahl, Thomsen, Line Elnif
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Archives & records
Bacteria
Bacterial infections
Biology and Life Sciences
Drug Resistance, Bacterial - drug effects
Health services
Humans
Infants (Newborn)
Infection
Infections
Invasive species
Medicine and Health Sciences
Microbial Sensitivity Tests
Neonates
Newborn babies
Older people
Penicillin
Penicillin G
Penicillins - pharmacology
Phenotypic variations
Recurrent infection
Streptococcal Infections - drug therapy
Streptococcal Infections - microbiology
Streptococcus agalactiae
Streptococcus agalactiae - drug effects
Streptococcus infections
Surveillance
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Summary:Antibiotic persistence is a phenomenon, where a small fraction of a bacterial population expresses a phenotypic variation that allows them to survive antibiotic treatment, which is lethal to the rest of the population. These cells are called persisters cells, and their occurrence has been associated with recurrent disease. Streptococcus agalactiae is a human pathobiont, able to cause invasive infections, and recurrent infections have been reported to occur in both newborns and adults. In this study, we demonstrated that S. agalactiae NEM316 can form persister cells when exposed to antibiotics from different classes. The frequency of persister cell formation was dependent on bacterial growth phase and the class of antibiotics. The ability to form persister cells in response to penicillin was shown to be a general trait among different clinical S. agalactiae isolates, independent of sero- and sequence-type. Taken together, this study shows the existence of antibiotic tolerant S. agalactiae persister cells, which may explain why this bacterial species frequently persists after treatment of invasive infection and can be associated with recurrent disease.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0303271