The relationship between NLR, LDL-C/HDL-C, NHR and coronary artery disease

• Published in: PloS one 2024-07, Vol.19 (7), p.e0290805
• Main Authors: Yuan, Shuaishuai, Li, Lingling, Pu, Tian, Fan, Xizhen, Wang, Zheng, Xie, Pailing, Li, Peijun
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - blood; Acute coronary syndromes; Aged; Analysis; Angiography; Arteriosclerosis; Atherosclerosis; Biology and Life Sciences; Biomarkers; Blood; Body mass index; Body size; Cardiac patients; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Cholesterol, HDL; Cholesterol, HDL - blood; Cholesterol, LDL; Cholesterol, LDL - blood; Coronary Angiography; Coronary artery disease; Coronary Artery Disease - blood; Coronary heart disease; Coronary vessels; Correlation analysis; Density; Diabetes; Diabetes mellitus; Dyslipidemia; Eosinophils; Female; Health aspects; Heart attacks; Heart diseases; High density lipoprotein; Hospitals; Humans; Hypertension; Inflammation; Lesions; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lipids; Low density lipoprotein; Low density lipoproteins; Lymphocytes; Male; Medical examination; Medical imaging; Medical research; Medicine and Health Sciences; Medicine, Experimental; Metabolism; Middle Aged; Monocytes; Mortality; Neutrophils; Patients; Physiological aspects; Prediction models; Regression analysis; Retrospective Studies; Risk assessment; Risk Factors; Sensitivity; Smoking; Statistical analysis; Triglycerides; Variables; Vein & artery diseases
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0290805

Chronic inflammation and dyslipidemia are key risk factors for atherosclerotic cardiovascular diseases. We retrospectively explored the association between the neutrophil to lymphocyte ratio (NLR), the ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C), and the neutrophil to HDL-C ratio (NHR), and the severity of coronary lesions in patients with acute coronary syndrome (ACS). In June 2023, we selected 1210 patients who were diagnosed with ACS based on chest pain from January 2017 to December 2022. Of these, 1100 patients with abnormal coronary angiography were categorized into the experimental group, and 110 patients with normal coronary angiography were classified as the control group. We collected routine blood tests, lipid profiles, and coronary angiography results at admission (before coronary angiography). Patients were then stratified into a control group (Gensini score = 0) and an experimental group (Gensini score = 0) based on the Gensini score. The experimental group was further divided into a low score group (Gensini score < 69) and a high score group (Gensini score ≥ 69). 1. Statistically significant differences were observed between the control and experimental groups in terms of gender, age, body mass index (BMI), hypertension, diabetes, smoking history, and counts of neutrophils (NEU), lymphocytes (LYM), monocytes (MON), eosinophils (EOS), red cell distribution width (RDW), total cholesterol (TC), HDL-C, LDL-C, NLR, LDL-C/HDL-C, and NHR (P