Three months use of Hybrid Closed Loop Systems improves glycated hemoglobin levels in adolescents and children with type 1 diabetes: A meta-analysis

Longer outpatient studies have demonstrated that hybrid closed loop (HCL) use has led to a concomitant reduction in glycated hemoglobin(HbA1c) by 0.3%-0.7%. However, reports have also indicated that HbA1c levels are not declined in the long-term use of HCL. Therefore, we wonder that 3 months use of...

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Bibliographic Details
Published in:PloS one 2024-08, Vol.19 (8), p.e0308202
Main Authors: Wang, Yuan-Yuan, Ying, Hui-Min, Tian, Fang, Qian, Xiao-Lu, Zhou, Zhen-Feng
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Bias
Biology and Life Sciences
Blood Glucose - analysis
Child
Children
Closed loop systems
Closed loops
Coefficient of variation
Collaboration
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Drug delivery systems
Drug therapy
Drugs
Feedback control
Glucose
Glycated Hemoglobin - analysis
Glycosylated hemoglobin
Health aspects
Hemoglobin
Heterogeneity
Humans
Hypoglycemia
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Hypotheses
Infusion pumps
Insulin
Insulin - administration & dosage
Insulin - therapeutic use
Insulin Infusion Systems
Medicine and Health Sciences
Meta-analysis
Missing data
Pediatric research
Pediatrics
People and Places
Physical Sciences
Physiological aspects
Research and Analysis Methods
Sensors
Standard of care
Teenagers
Type 1 diabetes
Vehicles
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Summary:Longer outpatient studies have demonstrated that hybrid closed loop (HCL) use has led to a concomitant reduction in glycated hemoglobin(HbA1c) by 0.3%-0.7%. However, reports have also indicated that HbA1c levels are not declined in the long-term use of HCL. Therefore, we wonder that 3 months use of HCL could improve glycated hemoglobin levels in adolescents and children with T1D. Relevant studies were searched electronically in the Cochrane Library, PubMed, and Embase utilizing the key words "Pediatrics or Child or Adolescent", "Insulin Infusion Systems" and "Diabetes Mellitus" from inception to 17th March 2024 to evaluate the performance of HCL on HbA1c in adolescents, and children with T1D. Nine studies involving 927 patients were identified. Three months use of HCL show a beneficial effect on HbA1c management (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0308202