Loneliness and the persistence of fear: Perceived social isolation reduces evaluative fear extinction

• Published in: PloS one 2024-08, Vol.19 (8), p.e0303895
• Main Authors: Hornstein, Erica, Lazar, Lee, Eisenberger, Naomi
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Animals; Biological diversity conservation; Biology and Life Sciences; Classical conditioning; Extinction (Learning); Extinction behavior; Extinction, Psychological; Fear; Fear & phobias; Fear - psychology; Fear conditioning; Female; Health aspects; Humans; Investigations; Learning; Loneliness; Loneliness - psychology; Male; Medicine and Health Sciences; Mental health; Physiology; Social bonds; Social discrimination learning; Social interactions; Social isolation; Social Isolation - psychology; Social Sciences; Social support; Vigilance; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0303895

Loneliness has been linked to a host of harmful physical and mental health outcomes, detrimental effects that may stem from increases in threat-responding caused by altered fear learning in lonely individuals. In particular, the heightened threat-vigilance that is a hallmark of loneliness may augment the processes by which fear learning occurs, ultimately resulting in a greater number of perceived threatening cues in the environment. However, almost no research has examined how loneliness alters fear learning processes in humans. Here, we investigated the effect of loneliness on fear learning during an evaluative learning procedure in which participants (n = 782) were taught to associate fearful, positive, or neutral control stimuli with neutral images. Results showed that reduced extinction of evaluative fear associations occurred in high (vs. low) lonely individuals, but there was no difference in extinction of evaluative appetitive (also known as positive or reward) associations, suggesting this effect is specific to fear learning. In addition to shedding light on the link between loneliness and poor health, these results represent an important step forward in the growing understanding of the powerful impact of social bonds on fear learning processes.