The uric acid/albumin ratio might be a better indicator for predicting repeat revascularization in young patients with acute coronary syndrome: Beyond inflammatory biomarkers

• Published in: PloS one 2024-08, Vol.19 (8), p.e0306178
• Main Authors: Oflar, Ersan, Karabulut, Dilay, Yıldız, Cennet, Sinoplu, Hasan Ali, Dönmez, Esra, Koyuncu, Atilla, Özcan, Sevgi, Çağlar, Nihan Turhan
• Format: Article
• Language: English
• Subjects: Acute Coronary Syndrome - blood; Acute Coronary Syndrome - surgery; Acute coronary syndromes; Adult; Albumin; Albumins; Analysis; Atherosclerosis; Biological markers; Biology and Life Sciences; Biomarkers; Biomarkers - blood; Cardiovascular disease; Care and treatment; Cholesterol; Coronary Angiography; Coronary heart disease; Coronary vessels; Diagnosis; Female; Health aspects; Heart attacks; High density lipoprotein; Hospitals; Humans; Implants; Inflammation - blood; Leukocytes (neutrophilic); Male; Medical records; Medicine and Health Sciences; Middle Aged; Myocardial Revascularization; Oxidative stress; Patients; Percutaneous Coronary Intervention; Performance prediction; Physical Sciences; Prognosis; Proteins; Regression analysis; Serum Albumin - analysis; Serum Albumin - metabolism; Stents; Syntax; Uric acid; Uric Acid - blood
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0306178

Despite advancements in percutaneous and surgical revascularization techniques, nearly 20% of patients who undergo myocardial revascularization need repeat revascularization. Recently, identified as a prognostication factor for adverse cardiovascular events, the uric acid/albumin ratio (UAR) serves as a new marker for assessing inflammation and oxidative stress. Our objective was to investigate the association between UAR levels and repeat revascularization in young patients with acute coronary syndrome (ACS). We enrolled 371 patients with ACS who were under the age of 55 years and who had previously undergone primary percutaneous coronary intervention. Due to their recurrent symptoms, these patients underwent subsequent coronary angiographic examination. The study cohort was splitted into two groups based on whether repeat revascularization was needed. The study and control groups consisted of 99 and 272 patients, respectively. The mean age of the patients in the study cohort was 41.99±4.99 years. Patients who needed repeat revascularization, in comparison to those who did not, exhibited significantly greater levels of the UAR and uric acid, along with lower levels of neutrophils, stent diameter and high density lipoprotein-cholesterol. Additionally, they had more complex disease, as described by the SYNTAX score. To identify the influential factors associated with repeat revascularization, multivariate logistic regression was performed. SYNTAX score, stent diameter, uric acid levels and the UAR were predictive of the need for repeat revascularization. UAR was found to be an inexpensive, easily accessible marker for identifying young patients with ACS requiring repeat revascularization.