Epidemiology of acute kidney injury in the clinical emergency: A prospective cohort study at a high-complexity public university hospital in São Paulo, Brazil

Southern Hemisphere countries have been underrepresented in epidemiological studies on acute kidney injury (AKI). The objectives of this study were to determine the frequency, risk factors, and outcomes of AKI in adult hospitalized patients from the emergency department of a public high-complexity t...

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Bibliographic Details
Published in:PloS one 2024-09, Vol.19 (9), p.e0309949
Main Authors: Azevedo, Flávia Barros de, Samaan, Farid, Zanetta, Dirce Maria Trevisan, Yu, Luis, Velasco, Irineu Tadeu, Burdmann, Emmanuel de Almeida
Format: Article
Language:English
Subjects:
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Acute renal failure
Adult
Aged
Brazil
Brazil - epidemiology
Cardiovascular diseases
Chronic kidney failure
Comorbidity
Complexity
Congestive heart failure
Creatinine
Death
Dehydration
Demographic aspects
Diabetes mellitus
Edema
Emergency medical care
Emergency medical services
Emergency Service, Hospital - statistics & numerical data
Epidemiology
Female
Health aspects
Heart diseases
Heart failure
Hospital Mortality
Hospitalization - statistics & numerical data
Hospitals
Hospitals, University
Humans
Hypertension
Hypotension
Kidney diseases
Kidneys
Liver
Liver diseases
Male
Medical research
Medicine and Health Sciences
Medicine, Experimental
Middle Aged
Mortality
Nonsteroidal anti-inflammatory drugs
Patient outcomes
Patients
Prospective Studies
Risk Factors
Southern Hemisphere
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Summary:Southern Hemisphere countries have been underrepresented in epidemiological studies on acute kidney injury (AKI). The objectives of this study were to determine the frequency, risk factors, and outcomes of AKI in adult hospitalized patients from the emergency department of a public high-complexity teaching hospital in the city of São Paulo, Brazil. Observational and prospective study. AKI was defined by the KDIGO guidelines (Kidney Disease: Improving Global Outcomes) using only serum creatinine. Among the 731 patients studied (age: median 61 years, IQR 47-72 years; 55% male), 48% had hypertension and 28% had diabetes as comorbidities. The frequency of AKI was 52.1% (25.9% community-based AKI [C-AKI] and 26.3% hospital-acquired AKI [H-AKI]). Dehydration, hypotension, and edema were found in 29%, 15%, and 15% of participants, respectively, at hospital admission. The in-hospital and 12-month mortality rates of patients with vs. without AKI were 25.2% vs. 11.1% (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0309949