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Sex differences in outcomes of patients undergoing on-pump coronary artery bypass grafting surgery

There are controversies regarding the impact of sex on mortality and postoperative complications in patients undergoing on-pump coronary artery bypass grafting (CABG), although some studies demonstrate comparable outcomes. This study sought to evaluate sex differences regarding risk factors associat...

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Bibliographic Details
Published in:PloS one 2024-09, Vol.19 (9), p.e0306902
Main Authors: Ferreira, Débora Klein, Petzold, Aline Petracco, Zawislak, Rafael Braccio, Oliveira, Jarbas Rodrigues de, Wagner, Mario Bernardes, Piantá, Ricardo Medeiros, Kalil, Renato Abdala Karam, Guaragna, Joao Carlos Vieira da Costa, Bodanese, Luiz Carlos
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Language:English
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Summary:There are controversies regarding the impact of sex on mortality and postoperative complications in patients undergoing on-pump coronary artery bypass grafting (CABG), although some studies demonstrate comparable outcomes. This study sought to evaluate sex differences regarding risk factors associated with hospital mortality and postoperative clinical outcomes among patients undergoing isolated on-pump CABG. We conducted a retrospective observational cohort study of patients who underwent isolated on-pump CABG from January 1996 to January 2020. Patients were divided into two groups (male and female) and compared regarding preoperative characteristics, surgical technical variables, and in-hospital outcomes. All-cause mortality between groups was compared using logistic regression. Risk factors for mortality, along with their respective odds ratios (OR), were separately assessed using a logistic regression model with p-values for interaction. We analyzed 4,882 patients, of whom 31.6% were female. Women exhibited a higher prevalence of age >75 years (12.2% vs 8.3%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0306902