Sleep patterns, genetic susceptibility, and venous thromboembolism: A prospective study of 384,758 UK Biobank participants

• Published in: PloS one 2024-09, Vol.19 (9), p.e0309870
• Main Authors: Bai, Jiaxin, Yang, Ziyu, Jia, Yu, Yu, Jing, Jiang, Wenli, Liu, Yi, Li, Fanghui, Zeng, Rui, Wan, Zhi, Lei, Yi, Liao, Xiaoyang, Li, Dongze, Zhao, Qian
• Format: Article
• Language: English
• Subjects: Adult; Aged; Behavior; Biobanks; Biological Specimen Banks; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Correlation; Daytime; Diabetes; Disease prevention; Disease susceptibility; Ethics; Exercise; Female; Genetic analysis; Genetic aspects; Genetic Predisposition to Disease; Health aspects; Health risks; Humans; Hypertension; Insomnia; Interactive computer systems; Lifestyles; Male; Medical research; Medicine, Experimental; Middle Aged; Pattern analysis; Peripheral vascular diseases; Physiological aspects; Physiology; Proportional Hazards Models; Prospective Studies; Pulmonary arteries; Questionnaires; Regression analysis; Regression models; Risk Factors; Secondary analysis; Sleep; Sleep - genetics; Sleep - physiology; Sleep and wakefulness; Sleep disorders; Sleepiness; Sociodemographics; Statistical analysis; Susceptibility; Thromboembolism; Thrombosis; UK Biobank; United Kingdom - epidemiology; Veins & arteries; Venous Thromboembolism - epidemiology; Venous Thromboembolism - genetics
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0309870

Although healthy sleep patterns have been linked to a lower risk of cardiovascular disease in earlier research, it is unclear how beneficial they are for venous thromboembolism (VTE). This research aimed to examine the correlation between sleep patterns, genetic susceptibility, and VTE. In the UK Biobank cohort, healthy sleep behaviors were defined as early chronotype, 7-8 hours of sleep each day, no snoring, infrequent insomnia, and infrequent daytime sleepiness. Each of the five criteria was given 1 point, creating a healthy sleep score ranging from 0 to 5. Cox proportional hazards regression models were utilized to examine the associations between genetic susceptibility, healthy sleep score and VTE. The UK Biobank study included 384,758 participants aged 56.6 ± 8.0 years. After a median of 11.9 years of follow-up, 8,885 (2.3%) participants were diagnosed with VTE. A healthy sleep score inversely affected VTE risk. For participants with a score of 5, the hazard ratio of VTE was 0.813 (95% confidence interval: 0.758-0.873, P