The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media

Ithildin is an open-source library and framework for efficient parallelized simulations of excitable media, written in the C++ programming language. It uses parallelization on multiple CPU processors via the message passing interface (MPI). We demonstrate the library's versatility through a ser...

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Bibliographic Details
Published in:PloS one 2024-09, Vol.19 (9), p.e0303674
Main Authors: Kabus, Desmond, Cloet, Marie, Zemlin, Christian, Bernus, Olivier, Dierckx, Hans
Format: Article
Language:English
Subjects:
Analysis
Anisotropy
C plus plus
Chemical reaction, Rate of
Computer and Information Sciences
Computer Simulation
Diffusion
Diffusion bonding (Metals)
Electrophysiology
Engineering and Technology
Evaluation
Geometry
Heart
Humans
Message passing
Models, Cardiovascular
Numerical analysis
Physical Sciences
Programming Languages
Research and Analysis Methods
Simulation
Software
Variables
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Description
Summary:Ithildin is an open-source library and framework for efficient parallelized simulations of excitable media, written in the C++ programming language. It uses parallelization on multiple CPU processors via the message passing interface (MPI). We demonstrate the library's versatility through a series of simulations in the context of the monodomain description of cardiac electrophysiology, including the S1S2 protocol, spiral break-up, and spiral waves in ventricular geometry. Our work demonstrates the power of Ithildin as a tool for studying complex wave patterns in cardiac tissue and its potential to inform future experimental and theoretical studies. We publish our full code with this paper in the name of open science.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0303674