Surgical modeling of Chiari-like malformation in rats: Insights from canine morphology

Chiari-like malformation in dogs and Chiari malformation type 1 in humans are conditions characterized by a relatively small caudal cranial fossa, leading to cerebellar herniation. This study aimed to develop a rat model of Chiari-like malformation using surgical techniques based on morphological ch...

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Bibliographic Details
Published in:PloS one 2024-09, Vol.19 (9), p.e0310505
Main Authors: Jung, Jae-Hwan, Cho, Chang-Hyeon, Shin, Sang-Yoon, Chung, Eun-Ji, Seo, Da-Eun, Kim, Woo-Suk, Yoon, Hun-Young
Format: Article
Language:English
Subjects:
Animal experimentation
Animal models
Animals
Arnold-Chiari deformity
Arnold-Chiari Malformation - diagnostic imaging
Arnold-Chiari Malformation - pathology
Arnold-Chiari Malformation - veterinary
Biology and Life Sciences
Brain
Brain research
Care and treatment
Cerebellum
Congenital defects
Diagnosis
Disease Models, Animal
Dogs
Evaluation
Female
Magnetic resonance
Magnetic Resonance Imaging
Male
Medicine and Health Sciences
Morphology
Neural tube defects
Physical characteristics
Rats
Research and Analysis Methods
Retrospective Studies
Skull
Software
Veterinary medicine
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Summary:Chiari-like malformation in dogs and Chiari malformation type 1 in humans are conditions characterized by a relatively small caudal cranial fossa, leading to cerebellar herniation. This study aimed to develop a rat model of Chiari-like malformation using surgical techniques based on morphological characteristics observed in dogs. Endocranial magnetic resonance images of both normal dogs and dogs diagnosed with Chiari-like malformation were retrospectively analyzed. Measurements of the caudal cranial fossa volume, rostral and medial fossa volume, and volume index were taken. The differences in caudal cranial fossa volume and volume index between normal dogs and those diagnosed with Chiari-like malformation were then utilized to create a rat model of Chiari-like malformation through surgical intervention. The measurements were conducted on both the rat Chiari-like malformation models and normal rats, with each measurement taken twice and the mean values calculated. Significant differences were found between normal dogs and dogs diagnosed with Chiari-like malformation in terms of the volume of the caudal cranial fossa (27.62% reduction) and the volume index (23.36% reduction) (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0310505