HNL Dimer in plasma is a unique and useful biomarker for the monitoring of antibiotic treatment in sepsis

Sepsis is a growing problem worldwide and associated with high mortality and morbidity. The early and accurate diagnosis and effective supportive therapy are critical for combating mortality. The aim of the study was to compare the kinetics of four biomarkers in plasma in patients admitted to ICU in...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2024-09, Vol.19 (9), p.e0310987
Main Authors: Venge, Per, Peterson, Christer, Xu, Shengyuan, Larsson, Anders, Johansson, Joakim, Tydén, Jonas
Format: Article
Language:English
Subjects:
Age
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Biological markers
Biology and Life Sciences
Biomarkers
Biomarkers - blood
Blood
Blood proteins
Body fluids
CAP37 protein
Consent
Dimers
Dosage and administration
Drug Monitoring - methods
Drug therapy
Drug utilization
Epithelial cells
Epithelium
Ethics
Female
Health aspects
Health services
Heparin
Humans
Intensive Care Units
Leukocytes (neutrophilic)
Lipocalin
Lipocalin-2 - blood
Male
Measurement
Medical examination
Medical research
Medicine and Health Sciences
Medicine, Experimental
Methods
Middle Aged
Morbidity
Mortality
Neutrophils
Patients
Physical Sciences
Plasma
Procalcitonin
Procalcitonin - blood
Regression analysis
Review boards
Sepsis
Sepsis - blood
Sepsis - drug therapy
Software
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis is a growing problem worldwide and associated with high mortality and morbidity. The early and accurate diagnosis and effective supportive therapy are critical for combating mortality. The aim of the study was to compare the kinetics of four biomarkers in plasma in patients admitted to ICU including sepsis and during antibiotics treatment. The biomarkers evaluated were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total and PCT (Procalcitonin). Plasma was obtained at admission to ICU and during follow-up at days 2 and 3. Antibiotic treatment was started or reviewed on admission to ICU. The results were compared to SOFA and KDIGO-scores and to survival. 277 patients admitted to ICU were included of which 30% had sepsis. The other groups were categorized as miscellaneous, other medical and trauma. The plasma concentrations of all four biomarkers were highly elevated with the highest concentrations in sepsis patients. During the follow-up period HNL Dimer decreased already day 2 and further so day 3 (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0310987