Perinatal and early life risk factors of adverse early childhood developmental outcomes: Protocol for systematic review using socioecological model

• Published in: PloS one 2024-10, Vol.19 (10), p.e0311500
• Main Authors: Atalell, Kendalem Asmare, Pereira, Gavin, Duko, Bereket, Nyadanu, Sylvester Dodzi, Tessema, Gizachew A
• Format: Article
• Language: English
• Subjects: Age; Biology and Life Sciences; Child; Child care; Child Development; Child development deviations; Child, Preschool; Childhood; Children; Children & youth; Childrens health; Citation management software; Communication; Comparators; Design factors; Developmental disabilities; Early childhood education; Exposure; Female; Geographical distribution; Geographical locations; Global health; Health aspects; Health promotion; Humans; Infant; Infant, Newborn; Influence; Maternal & child health; Medicine and Health Sciences; Mental health; Nutrition; Observational studies; People and Places; Perinatal exposure; Pollutants; Population studies; Pregnancy; Prenatal care; Prenatal development; Public health; Research and Analysis Methods; Reviews; Risk Factors; Social Sciences; Study Protocol; Systematic review; Systematic Reviews as Topic
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0311500

Adverse early childhood developmental outcomes impact later schooling and adulthood life courses. However, there needs to be more comprehensive evidence on the effect of various perinatal and early life risk exposures. Hence, we aimed to systematically identify the various perinatal and early childhood risk factors using a socioecological model to inform appropriate prevention strategies. The systematic review will adhere to the 2020 PRISMA guidelines. The protocol was registered in PROSPERO with a registration number of CRD42023447352. We will systematically search for articles on adverse early childhood developmental outcomes, which include physical, cognitive, language and communication and social-emotional development from main databases, such as EMBASE, Medline, Global Health, PsycINFO, CINAHL and Web of Science Core Collection, dating from 2000. We will use Population, Exposure, Comparator, Outcome and Study Design (PECOS) criteria to select eligible studies for our review: 1) Population includes children in early childhood age (i.e., up to eight years) undergoing developmental assessments. 2) Exposure: various perinatal and early life risk factors. 3) Comparators: Children with no or low levels of exposure to the risk factors. 4) Outcome: adverse early childhood developmental outcome. 5) Study design: all observational studies that report the prevalence or incidence of adverse early childhood developmental outcomes and associated risk factors published since 2000. There will be no restriction based on country of origin or geographical location except language (only published in English). Textual and narrative synthesis using the socioecological model will be used to synthesise the data.