Diffuse white matter pathology in multiple sclerosis during treatment with dimethyl fumarate-An observational study of changes in normal-appearing white matter using proton magnetic resonance spectroscopy

Multiple sclerosis (MS) is an inflammatory demyelinating disease with neurodegenerative features causing risk for neurologic irreversible disability over time. Examination of normal-appearing white matter (NAWM) changes in MS by proton magnetic resonance spectroscopy (1H-MRS), may detect diffuse whi...

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Bibliographic Details
Published in:PloS one 2024-10, Vol.19 (10), p.e0309547
Main Authors: Tisell, Anders, Söderberg, Kristina, Link, Yumin, Lundberg, Peter, Mellergård, Johan
Format: Article
Language:English
Subjects:
Adult
Aspartic Acid - analogs & derivatives
Autoimmune diseases
Biology and Life Sciences
Care and treatment
Cerebrospinal fluid
Cross-Sectional Studies
Demyelinating diseases
Demyelination
Dimethyl Fumarate - therapeutic use
Disease
Disease control
Diseases
Evaluation
Female
Gliosis
Humans
Inflammation
Inositol
Inositol - metabolism
Inositols
Magnetic resonance
Magnetic resonance imaging
Magnetic resonance spectroscopy
Male
Medicine and Health Sciences
Metabolites
Middle Aged
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - drug therapy
Multiple Sclerosis - metabolism
Multiple Sclerosis - pathology
N-Acetylaspartate
N-Acetylaspartylglutamic acid
Neurodegeneration
Nuclear magnetic resonance spectroscopy
Observational studies
Pathology
Patient outcomes
Proton magnetic resonance
Proton magnetic resonance spectroscopy
Proton Magnetic Resonance Spectroscopy - methods
Research and Analysis Methods
Spectroscopic analysis
Spectroscopy
Spectrum analysis
Substantia alba
Tissues
White Matter - diagnostic imaging
White Matter - drug effects
White Matter - metabolism
White Matter - pathology
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Summary:Multiple sclerosis (MS) is an inflammatory demyelinating disease with neurodegenerative features causing risk for neurologic irreversible disability over time. Examination of normal-appearing white matter (NAWM) changes in MS by proton magnetic resonance spectroscopy (1H-MRS), may detect diffuse white matter pathology that is associated with neurodegeneration. In this observational study of in total twenty-six patients with MS, starting treatment with dimethyl fumarate (DMF), we measured the absolute concentration of metabolites in periventricular NAWM using 1H-MRS at baseline and after one and three years of treatment. Metabolite concentrations were analyzed both cross-sectionally, in relation to 10 controls and longitudinally in relation to disease activity. Patients with MS had higher concentrations of myo-inositol (mIns) in NAWM at baseline compared with controls (mean 5.98 ± 1.37 (SD) and 4.32 ± 1.16 (SD), p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0309547