Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes

• Published in: PloS one 2024-11, Vol.19 (11), p.e0310964
• Main Authors: Qi, Xiang, Zhu, Zheng, Luo, Huabin, Schwartz, Mark D, Wu, Bei
• Format: Article
• Language: English
• Subjects: Adults; Age; Age Factors; Aged; Aging; Alzheimer's disease; Biology and Life Sciences; Body mass index; Complications and side effects; Confidence intervals; Dementia; Dementia - diagnosis; Dementia - epidemiology; Dementia - etiology; Dementia disorders; Demographics; Development and progression; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; Diagnosis; Female; Hazard assessment; Health aspects; Health surveys; Humans; Hyperglycemia; Hypertension; Hypoglycemic agents; Insulin resistance; Male; Medicine and Health Sciences; Middle Aged; Obesity; Obesity - complications; Obesity - epidemiology; Older people; Population studies; Proportional Hazards Models; Prospective Studies; Questionnaires; Risk; Risk Factors; Self report; Statistical models; Surveys; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0310964

While Type 2 Diabetes Mellitus (T2DM) prevalence is increasing among younger individuals, few studies have examined how age at T2DM diagnosis relates to dementia risk in diabetic populations. We aimed to investigate the association between age at T2DM diagnosis and subsequent dementia risk, and to determine whether obesity moderates this relationship. We conducted a prospective cohort study using data from the Health and Retirement Study (2002-2016) matched with its 2003 Diabetes Mail-Out Survey. The study included 1,213 dementia-free adults aged ≥50 with diagnosed T2DM. Primary exposures were age at T2DM diagnosis (categorized as