Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: A systematic review

• Published in: PloS one 2024-11, Vol.19 (11), p.e0314280
• Main Authors: Abdull Rahim, Unwaniah, Mustapa, Marami, Mohamed Shakrin, Nik Noorul Shakira, Nurdin, Armania, Mohamad Taridi, Nursiati, Yusof, Yasmin Anum Mohd, Mad Nordin, Mariam Firdhaus, Che Roos, Nur Aishah
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Animal models; Animals; Anticancer properties; Antimitotic agents; Antineoplastic agents; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; BAX protein; Bcl-2 protein; Bioactive compounds; Biological activity; Cancer therapies; Care and treatment; Catechols - pharmacology; Catechols - therapeutic use; Cell culture; Cell growth; Cell Line, Tumor; Cervical cancer; Chemotherapy; Curcumin; Curcumin - pharmacology; Curcumin - therapeutic use; Fatty Alcohols - pharmacology; Fatty Alcohols - therapeutic use; Female; Gingerol; Health aspects; Human papillomavirus; Humans; Infections; Long-term effects; Malignancy; p53 Protein; Pharmacology; Pharmacology, Experimental; Physiological aspects; Phytochemicals; Radiation therapy; Reviews; Shogaols; Signal transduction; Signal Transduction - drug effects; Synergistic effect; Systematic review; Toxicity; Tumor cell lines; Turmeric; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Vaccination; Wnt protein; Xenotransplantation; Zingiber officinale - chemistry
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0314280

Cervical cancer ranked fourth most common malignancy among women worldwide despite the establishment of vaccination programmes. This systematic review evaluates the anti-cancer properties of turmeric and ginger bioactive compounds, specifically curcumin, 6/10-gingerol, and 6/10-shogaol, and their combination in cervical cancer through in-vitro and in-vivo models. A comprehensive electronic search was performed using Science Direct, PubMed, and Scopus from inception until the second week of June 2024 for studies published in English. Only studies investigating the effects of curcumin, gingerol, shogaol, and/or their combination in human cervical cancer cell lines and/or rodent animal models implanted with cervical cancer xenografts were included. Altogether, 27 studies were included in this review. The evidence gathered indicated that curcumin, 6/10-gingerol and 6-shogaol exert their anticancer action through modulation of cell signalling pathways, including AMPK, WNT, PI3K/AKT, and NF-κB pathway, and mediators including Bax/Bcl2, TNF-α, EGFR, COX-2, caspases-3, -9, p53, and pRb. However, the synergistic effect of these bioactive compounds is not known due to lack of evidence. In conclusion, curcumin, 6/10-gingerols, and 6-shogaols hold promise as therapeutic agents for cervical cancer. Yet, further research is essential to understand their combined efficacy, emphasising the need for additional studies exploring the synergistic anticancer effects of these bioactive compounds. Additional factors to explore include long-term effects and susceptibility of chemoresistant cervical cancer cells towards curcumin, shogaols, and gingerols.