Cross-sectional study of lung cancer patients as a potential high-risk factor for abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is more common in Non-small cell lung cancer (NSCLC) patients. Considering that ruptured AAA is potentially fatal, timely management of AAA would result in long-term survival benefits. We assess the prevalence and characteristics of AAA in resectable NSCLC patients wh...

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Published in:PloS one 2025-01, Vol.20 (1), p.e0315898
Main Authors: Gwon, Hye Ran, Woo, A La, Yong, Seung Hyun, Park, Young Mok, Kim, Song Yee, Kim, Eun Young, Jung, Ji Ye, Kang, Young Ae, Park, Moo Suk, Kang, Du-Young, Park, Seong Yong, Lee, Sang Hoon, Kwon, Jun Seong
Format: Article
Language:English
Subjects:
Abdomen
Abdominal aneurysm
Age
Aorta
Aortic aneurysms
Chronic obstructive pulmonary disease
Complications and side effects
Computed tomography
Coronary artery disease
Coronary vessels
Cross-sectional studies
Demographic aspects
Diagnosis
Ethics
Heart diseases
Hospitals
Hypertension
Life expectancy
Lung cancer
Lung cancer, Non-small cell
Lung diseases
Medical prognosis
Medicine and Health Sciences
Metabolic disorders
Mortality
Multivariable control
Non-small cell lung carcinoma
Regression analysis
Review boards
Risk factors
Small cell lung carcinoma
Smoking
Statistical analysis
Surgery
Surveillance
Survival analysis
Tomography
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container_title PloS one
container_volume 20
creator Gwon, Hye Ran
Woo, A La
Yong, Seung Hyun
Park, Young Mok
Kim, Song Yee
Kim, Eun Young
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kang, Du-Young
Park, Seong Yong
Lee, Sang Hoon
Kwon, Jun Seong
description Abdominal aortic aneurysm (AAA) is more common in Non-small cell lung cancer (NSCLC) patients. Considering that ruptured AAA is potentially fatal, timely management of AAA would result in long-term survival benefits. We assess the prevalence and characteristics of AAA in resectable NSCLC patients who would benefit from AAA surveillance. 1,019 resectable NSCLC patients in Severance and Kangbuk Samsung Hospitals were reviewed from January 2019 to November 2020. The control group comprised 2,899 cancer-free people who had a health check-up CT scan in Severance between January 2018 and December 2019. Among resectable primary NSCLC patients, 39/1,019 (3.8%; odds ratio [OR], 19.19; 95% confidence interval [CI], 8.10-46.46) had AAA compared with 6/2,899 (0.2%) in the control (P
doi_str_mv 10.1371/journal.pone.0315898
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Considering that ruptured AAA is potentially fatal, timely management of AAA would result in long-term survival benefits. We assess the prevalence and characteristics of AAA in resectable NSCLC patients who would benefit from AAA surveillance. 1,019 resectable NSCLC patients in Severance and Kangbuk Samsung Hospitals were reviewed from January 2019 to November 2020. The control group comprised 2,899 cancer-free people who had a health check-up CT scan in Severance between January 2018 and December 2019. Among resectable primary NSCLC patients, 39/1,019 (3.8%; odds ratio [OR], 19.19; 95% confidence interval [CI], 8.10-46.46) had AAA compared with 6/2,899 (0.2%) in the control (P&lt;0.001). In multivariable regression analysis, male (OR, 13.24; 95% CI, 1.50-117.48; P = 0.020), aging (OR, 1.10; 95% CI, 1.04-1.15; P&lt;0.001), current smoker (OR, 4.20; 95% CI, 1.20-14.62; P = 0.024), and coronary artery disease (OR, 3.13; 95% CI, 1.48-6.62; P = 0.003) were independent risk factors for AAA in NSCLC. The present study found that the incidence of AAA in resectable early-stage lung cancer patients was significantly higher than in the cancer-free control group. 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Considering that ruptured AAA is potentially fatal, timely management of AAA would result in long-term survival benefits. We assess the prevalence and characteristics of AAA in resectable NSCLC patients who would benefit from AAA surveillance. 1,019 resectable NSCLC patients in Severance and Kangbuk Samsung Hospitals were reviewed from January 2019 to November 2020. The control group comprised 2,899 cancer-free people who had a health check-up CT scan in Severance between January 2018 and December 2019. Among resectable primary NSCLC patients, 39/1,019 (3.8%; odds ratio [OR], 19.19; 95% confidence interval [CI], 8.10-46.46) had AAA compared with 6/2,899 (0.2%) in the control (P&lt;0.001). In multivariable regression analysis, male (OR, 13.24; 95% CI, 1.50-117.48; P = 0.020), aging (OR, 1.10; 95% CI, 1.04-1.15; P&lt;0.001), current smoker (OR, 4.20; 95% CI, 1.20-14.62; P = 0.024), and coronary artery disease (OR, 3.13; 95% CI, 1.48-6.62; P = 0.003) were independent risk factors for AAA in NSCLC. The present study found that the incidence of AAA in resectable early-stage lung cancer patients was significantly higher than in the cancer-free control group. Therefore, we suggest that early-stage NSCLC patients, especially smokers older than 60 years, undergo regular AAA surveillance as part of their lung cancer monitoring.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0315898</doi><tpages>e0315898</tpages><orcidid>https://orcid.org/0000-0003-2218-8959</orcidid><orcidid>https://orcid.org/0000-0002-5409-3172</orcidid><orcidid>https://orcid.org/0000-0002-8818-6115</orcidid><oa>free_for_read</oa></addata></record>
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subjects Abdomen
Abdominal aneurysm
Age
Aorta
Aortic aneurysms
Chronic obstructive pulmonary disease
Complications and side effects
Computed tomography
Coronary artery disease
Coronary vessels
Cross-sectional studies
Demographic aspects
Diagnosis
Ethics
Heart diseases
Hospitals
Hypertension
Life expectancy
Lung cancer
Lung cancer, Non-small cell
Lung diseases
Medical prognosis
Medicine and Health Sciences
Metabolic disorders
Mortality
Multivariable control
Non-small cell lung carcinoma
Regression analysis
Review boards
Risk factors
Small cell lung carcinoma
Smoking
Statistical analysis
Surgery
Surveillance
Survival analysis
Tomography
title Cross-sectional study of lung cancer patients as a potential high-risk factor for abdominal aortic aneurysm
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