Prevention of unplanned extubation in neonatal patients: Protocol for a systematic review and meta-analysis

Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered the fourth most common adverse event in neonatal intensive care units (NICU). This study aimed to des...

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Bibliographic Details
Published in:PloS one 2025-01, Vol.20 (1), p.e0314201
Main Authors: Pontes, Ludmylla Cristina de Faria, Pimenta, Isac Davidson Santiago Fernandes, de Medeiros, Gidyenne Christine Bandeira Silva, Guillén-Martínez, Daniel, Echevarria-Pérez, Paloma, Piuvezam, Grasiela, Capucho, Helaine Carneiro
Format: Article
Language:English
Subjects:
Adverse events
Airway Extubation - methods
Artificial respiration
Bias
Biology and Life Sciences
Birth weight
Clinical trials
Decision making
Extubation
Gestational age
Hemodynamics
Hospitals
Humans
Infant, Newborn
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Intubation
Intubation, Intratracheal - adverse effects
Latin American literature
Mechanical ventilation
Medical errors
Medicine and Health Sciences
Meta-analysis
Meta-Analysis as Topic
Methods
Neonatal intensive care
Neonates
Patients
Pediatric research
Physical Sciences
Population studies
Prevention
Research and Analysis Methods
Respiration, Artificial - adverse effects
Respiration, Artificial - methods
Safety management
Study Protocol
Systematic review
Systematic Reviews as Topic
Trachea
Ventilation
Ventilators
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Description
Summary:Unplanned extubation (UPE), defined as accidental removal of the endotracheal tube during mechanical ventilation or its replacement due to suspected obstruction or inadequate diameter, is considered the fourth most common adverse event in neonatal intensive care units (NICU). This study aimed to describe a systematic review and meta-analysis protocol that will identify and assess the effect of primary intervention measures designed to prevent UPE in NICU. A search will be carried out in the following databases: PubMed/Medline, EMBASE, Scopus, CINAHL, Cochrane Library, SciELO, and LILACS. Reviewers, in pairs and independently, will select the studies, perform data extraction and assess the methodological quality of the included studies using preestablished tools according to the type of study. The systematic review will provide evidence to present the main intervention measures used in the prevention of UPE during the care of critical neonatal patients. The systematic review and meta-analysis resulting from this protocol may provide important information regarding UPE in the neonatal population, which will help with decision-making and the implementation of safer clinical practices that focus on the reduction of adverse events, contributing to the improvement of service management and the safety of neonatal patients.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0314201