Signalling pathways involved in urotensin II induced ventricular myocyte hypertrophy

Sustained pathologic myocardial hypertrophy can result in heart failure(HF); a significant health issue affecting a large section of the population worldwide. In HF there is a marked elevation in circulating levels of the peptide urotensin II(UII) but it is unclear whether this is a result of hypert...

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Bibliographic Details
Published in:PloS one 2025-01, Vol.20 (1), p.e0313119
Main Authors: Al Ali, Hadeel S, Rodrigo, Glenn C, Lambert, David G
Format: Article
Language:English
Subjects:
Animals
Antibodies
Biology and Life Sciences
Ca2+/calmodulin-dependent protein kinase II
Calcium (reticular)
Calcium ions
Calcium signalling
Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism
Cardiac muscle
Cardiomegaly - chemically induced
Cardiomegaly - metabolism
Cardiomegaly - pathology
Cardiovascular diseases
Congestive heart failure
Development and progression
Extracellular signal-regulated kinase
Heart diseases
Heart enlargement
Heart failure
Heart Ventricles - metabolism
Heart Ventricles - pathology
Hypertrophy
Kinases
Leak channels
Male
MAP kinase
Medicine and Health Sciences
Membranes
Muscle contraction
Myocytes
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
p38 Mitogen-Activated Protein Kinases - metabolism
Peptides
Proteins
Rats
Rats, Sprague-Dawley
Receptor mechanisms
Receptors
Receptors, G-Protein-Coupled - metabolism
Risk factors
Sarcoplasmic reticulum
Signal transduction
Signal Transduction - drug effects
Urotensins - metabolism
Urotensins - pharmacology
Ventricle
Western blotting
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Summary:Sustained pathologic myocardial hypertrophy can result in heart failure(HF); a significant health issue affecting a large section of the population worldwide. In HF there is a marked elevation in circulating levels of the peptide urotensin II(UII) but it is unclear whether this is a result of hypertrophy or whether the high levels contribute to the development of hypertrophy. The aim of this study is to investigate a role of UII and its receptor UT in the development of cardiac hypertrophy and the signalling molecules involved. Ventricular myocytes isolated from adult rat hearts were treated with 200nM UII for 48hours and hypertrophy was quantified from measurements of length/width (L/W) ratio. UII resulted in a change in L/W ratio from 4.53±0.10 to 3.99±0.06; (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0313119