Toward Efficient Asymmetric Hydrogenation: Architectural and Functional Engineering of Chiral Molecular Catalysts

Asymmetric hydrogenation uses inexpensive, clean hydrogen gas and a very small amount of a chiral molecular catalyst, providing the most powerful way to produce a wide array of enantio-enriched compounds in a large quantity without forming any waste. The recent revolutionary advances in this field h...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (15), p.5356-5362
Main Authors: Noyori, Ryoji, Kitamura, Masato, Ohkuma, Takeshi, Halpern, Jack
Format: Article
Language:English
Subjects:
Catalysis
Catalysts
Engineering
Esters
Hydrogen
Hydrogenation
Ketones
Kinetics
Ligands
Organic chemistry
Perspectives
Physical chemistry
Solvents
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Summary:Asymmetric hydrogenation uses inexpensive, clean hydrogen gas and a very small amount of a chiral molecular catalyst, providing the most powerful way to produce a wide array of enantio-enriched compounds in a large quantity without forming any waste. The recent revolutionary advances in this field have entirely changed the synthetic approach to producing performance chemicals that require a high degree of structural precision. The means of developing efficient asymmetric hydrogenations is discussed from a mechanistic point of view.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0307928100