Requirement of c-myb in T Cell Development and in Mature T Cell Function

Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2004-10, Vol.101 (41), p.14853-14858
Main Authors: Lieu, Yen K., Kumar, Atul, Pajerowski, Anthony G., Rogers, Thomas J., Reddy, E. Premkumar, Vogt, Peter K.
Format: Article
Language:English
Subjects:
Alleles
Animals
Autoimmune Diseases - genetics
Biological Sciences
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - physiology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - physiology
Cell cycle
Cell Division
Cell growth
Cell Survival
Cells
Developmental biology
Exons
Flow Cytometry
Gene Expression Regulation
Genes, myb - genetics
Genotype
Lymph nodes
Mice
Mice, Knockout
Proto-Oncogene Proteins c-myb - deficiency
Proto-Oncogene Proteins c-myb - genetics
Restriction Mapping
Spleen
T lymphocytes
T-Lymphocytes - immunology
T-Lymphocytes - physiology
Thymocytes
Thymus Gland - immunology
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Summary:Previous reports have suggested that the protooncogene c-myb participates in T cell development in the thymus and mature T cell proliferation. We have generated two T cell-specific c-myb knockout mouse models, myb/LckCre and myb/CD4Cre. We have demonstrated that c-myb is required for the development of thymocytes at the DN3 stage, for survival and proliferation of double-positive thymocytes, for differentiation of single-positive CD4 and CD8 T cells, and for the proliferative responses of mature T cells. In addition, our data show that c-myb is directly involved in the formation of double-positive CD4+CD8+CD25+, CD4+CD25+, and CD8+CD25+ T cells, developmental processes that may imply a role for c-myb in autoimmune dysfunction.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0405338101