Mitochondrial Transfer between Cells Can Rescue Aerobic Respiration

Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2006-01, Vol.103 (5), p.1283-1288
Main Authors: Spees, Jeffrey L., Olson, Scott D., Whitney, Mandolin J., Prockop, Darwin J.
Format: Article
Language:English
Subjects:
Animal cells
Animals
Biological Sciences
Bone marrow
Bone Marrow Cells
Cell fusion
Cell growth
Cell Line
Cell Line, Tumor
Cell lines
Cells, Cultured
Cellular biology
Coculture Techniques
Culture Media - metabolism
Cultured cells
DNA, Mitochondrial - genetics
Fibroblasts
Fibroblasts - metabolism
Genetic Therapy
Genome
Green Fluorescent Proteins - metabolism
Humans
Ischemia
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Models, Genetic
Oxygen Consumption
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Protein Biosynthesis
Protein Transport
Somatic cells
Stem cells
Stem Cells - cytology
Time Factors
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Summary:Current theory indicates that mitochondria were obtained 1.5 billion years ago from an ancient prokaryote. The mitochondria provided the capacity for aerobic respiration, the creation of the eukaryotic cell, and eventually complex multicellular organisms. Recent reports have found that mitochondria play essential roles in aging and determining lifespan. A variety of heritable and acquired diseases are linked to mitochondrial dysfunction. We report here that mitochondria are more dynamic than previously considered: mitochondria or mtDNA can move between cells. The active transfer from adult stem cells and somatic cells can rescue aerobic respiration in mammalian cells with nonfunctional mitochondria.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0510511103