Loading…
Pten Deletion Leads to the Expansion of a Prostatic Stem/Progenitor Cell Subpopulation and Tumor Initiation
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers. Deletion of Pten in a murine model of prostate cancer recapitulates the disease progression seen in humans. Using defined cell lineage markers, we demonstrat...
Saved in:
Published in: | Proceedings of the National Academy of Sciences - PNAS 2006-01, Vol.103 (5), p.1480-1485 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers. Deletion of Pten in a murine model of prostate cancer recapitulates the disease progression seen in humans. Using defined cell lineage markers, we demonstrate that PTEN negatively regulates p63-positive prostatic basal cell proliferation without blocking differentiation. Concomitant with basal cell proliferation is the expansion of a prostate stem/progenitorlike subpopulation as evidenced by the progressive increase of stem cell antigen-1 (Sca-1)-and BCL-2-positive cells. This observation provides strong evidence that basal cell proliferation can be an initiating event for precancerous lesions. Sca-1⁺ and BCL-2⁺ progenitors may serve as cancer-initiating cells in this model. |
---|---|
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.0510652103 |