Resting-State Networks in the Infant Brain

In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as system-wide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is current...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2007-09, Vol.104 (39), p.15531-15536
Main Authors: Fransson, Peter, Skiöld, Beatrice, Horsch, Sandra, Nordell, Anders, Blennow, Mats, Lagercrantz, Hugo, Åden, Ulrika
Format: Article
Language:English
Subjects:
Adults
Animals
Auditory cortex
Babies
Behavior
Biological Sciences
Brain
Brain - growth & development
Brain - metabolism
Brain - physiology
Brain Mapping - methods
Cerebral hemispheres
Connectivity
Datasets
Female
Humans
Image Processing, Computer-Assisted
Infant
Infants
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicin och hälsovetenskap
Models, Neurological
Neurosciences
Rest
Sleep
Visual cortex
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Summary:In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as system-wide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the primary visual cortex, bilateral sensorimotor areas, bilateral auditory cortex, a network including the precuneus area, lateral parietal cortex, and the cerebellum as well as an anterior network that incorporated the medial and dorsolateral prefrontal cortex. These results suggest that resting-state networks driven by spontaneous signal fluctuations are present already in the infant brain. The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0704380104