Sequence physical properties encode the global organization of protein structure space

It is demonstrated that, properly represented, the amino acid composition of protein sequences contains the information necessary to delineate the global properties of protein structure space. A numerical representation of amino acid sequence in terms of a set of property factors is used, and the va...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2009-08, Vol.106 (34), p.14345-14348
Main Author: Rackovsky, S
Format: Article
Language:English
Subjects:
Abstract spaces
Algorithms
Amino acids
Architecture
Biological Sciences
Computer Simulation
Databases, Protein
Datasets
Eigenvectors
Hyperplanes
Molecular structure
Physical Phenomena
Principal components analysis
Property composition
Property titles
Protein Conformation
Proteins
Proteins - chemistry
Proteomics
Sequence Analysis, Protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is demonstrated that, properly represented, the amino acid composition of protein sequences contains the information necessary to delineate the global properties of protein structure space. A numerical representation of amino acid sequence in terms of a set of property factors is used, and the values of those property factors are averaged over individual sequences and then over sets of sequences belonging to structurally defined groups. These sequence sets then can be viewed as points in a 10-dimensional space, and the organization of that space, determined only by sequence properties, is similar at both local and global scales to that of the space of protein structures determined previously.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0903433106