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DNA Polymerase Activity Associated with RNA Tumor Viruses

C-type RNA viruses, originating in mouse, cat, hamster, and viper, catalyze the synthesis of DNA from its constituent deoxyribonucleoside triphosphates. Both the rate and extent of the reaction were significantly enhanced by brief treatment of the intact virus with ether. A proportion of the newly s...

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Published in:	Proceedings of the National Academy of Sciences - PNAS 1970-09, Vol.67 (1), p.143-147
Main Authors:	Hatanaka, M., Huebner, R. J., Gilden, R. V.
Format:	Article
Language:	English
Subjects:	Animals Antigens Biological Sciences: Biochemistry Cats Cricetinae DNA DNA - biosynthesis DNA Nucleotidyltransferases Enzyme activity Ethers Ethyl Ethers - pharmacology Leukemia Virus, Murine - enzymology Mice Oncogenic viruses Oncogenic Viruses - drug effects Oncogenic Viruses - enzymology Rauscher Virus - drug effects Rauscher Virus - enzymology RNA RNA Viruses - enzymology Snakes Vipers Viral RNA Virions Viruses
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container_end_page	147
container_issue	1
container_start_page	143
container_title	Proceedings of the National Academy of Sciences - PNAS
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creator	Hatanaka, M. Huebner, R. J. Gilden, R. V.
description	C-type RNA viruses, originating in mouse, cat, hamster, and viper, catalyze the synthesis of DNA from its constituent deoxyribonucleoside triphosphates. Both the rate and extent of the reaction were significantly enhanced by brief treatment of the intact virus with ether. A proportion of the newly synthesized DNA was associated with virions when intact virus was used as template; this was not the case with ether-treated virus. In both cases, DNA extracted from the reaction mixture sedimented slowly, at about 2-4 S.
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subjects	Animals Antigens Biological Sciences: Biochemistry Cats Cricetinae DNA DNA - biosynthesis DNA Nucleotidyltransferases Enzyme activity Ethers Ethyl Ethers - pharmacology Leukemia Virus, Murine - enzymology Mice Oncogenic viruses Oncogenic Viruses - drug effects Oncogenic Viruses - enzymology Rauscher Virus - drug effects Rauscher Virus - enzymology RNA RNA Viruses - enzymology Snakes Vipers Viral RNA Virions Viruses
title	DNA Polymerase Activity Associated with RNA Tumor Viruses
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