Species-Specific and Interspecific Antigenic Determinants Associated with the Structural Protein of Feline C-Type Virus

The group-specific protein of feline leukemia viruses has been isolated by isoelectric focusing. This protein has a molecular weight, calculated from sodium dodecyl sulfate-acrylamide gel electrophoresis, of 25,000 and forms a resolved band in such gels when disrupted virions are analyzed. This prot...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1971-05, Vol.68 (5), p.901-904
Main Authors: Oroszlan, S., Huebner, R. J., Gilden, R. V.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigens
Antigens - analysis
Biological Sciences: Immunology
Cat Diseases - microbiology
Cats
Complement Fixation Tests
Cross Reactions
Dogs
Electrophoresis, Disc
Epitopes
Epitopes - analysis
Feline leukemia virus
Gels
Guinea Pigs
Hamsters
Immunodiffusion
Isoelectric Focusing
Molecular weight
Moloney murine leukemia virus - immunology
Rats
Retroviridae - immunology
Species Specificity
Tumors
Viral Proteins - analysis
Viruses
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Description
Summary:The group-specific protein of feline leukemia viruses has been isolated by isoelectric focusing. This protein has a molecular weight, calculated from sodium dodecyl sulfate-acrylamide gel electrophoresis, of 25,000 and forms a resolved band in such gels when disrupted virions are analyzed. This protein contains both species-specific antigenic determinants, as well as inter-specific cross-reactive determinants, as an integral part of its structure.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.68.5.901