Divergence between Immunosuppression and Immunocompetence during Virus-Induced Leukemogenesis

Mice were infected with Friend leukemia virus and later immunized with either Vibrio cholerae vaccine or sheep erythrocytes. The primary antibody response to the bacteria (as judged by the number of plaque-forming cells) was slightly enhanced by the viral infection, whereas the response to sheep ery...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1971-08, Vol.68 (8), p.1862-1865
Main Authors: Cerny, Jan, McAlack, Robert F., Ceglowski, Walter S., Friedman, Herman
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibody Formation
Antigen-Antibody Reactions
Antigens
Bacteria
Biological Sciences: Immunology
Cell Aggregation
Cholera Vaccines
Erythrocytes
Erythrocytes - immunology
Female
Friend murine leukemia virus
Hemolytic Plaque Technique
Immunization
Immunosuppression
Infections
Leukemia
Leukemia, Experimental - etiology
Leukemia, Experimental - immunology
Male
Mice
Spleen
Spleen - immunology
Viruses
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Summary:Mice were infected with Friend leukemia virus and later immunized with either Vibrio cholerae vaccine or sheep erythrocytes. The primary antibody response to the bacteria (as judged by the number of plaque-forming cells) was slightly enhanced by the viral infection, whereas the response to sheep erythrocytes was inhibited. The difference appeared due to sensitization of mice to antigens crossreacting with those of sheep erythrocytes; no natural immunity to V. cholerae is detectable. However, the response of mice infected with Friend leukemia virus to a secondary challenge with the cholera bacteria was markedly inhibited. Even though the number of plaque-forming cells during the primary response was not reduced, accumulation of the cells in distinct splenic foci was suppressed. These results suggest that the effect of Friend leukemia virus on immunocompetent cells is selective. The immune response appears to be susceptible to leukemia virus-induced immunosuppression only when there has been a previous stimulation of immunocytes by antigen.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.68.8.1862