A Calcium-Dependent Mechanism for Synapse and Nerve Cell Membrane Modulation

A theory is presented according to which the neuronal membrane and synapses are influenced by membrane-bound S100 protein and a membrane-associated network of actin-like, 20- angstrom -diameter, coiled filaments and the competition by both proteins for Ca2+. The discussion is based on observations m...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1974-08, Vol.71 (8), p.2965-2968
Main Author: Hyden, Holger
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Antibodies
Antigen-Antibody Reactions
Antiserum
Biological Sciences: Cell Biology
Brain
Calcium - metabolism
Cell Differentiation
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Cell membranes
Cell Separation
Cells
Fluorescence
Immunologic Techniques
Membrane proteins
Microscopy, Electron
Models, Neurological
Models, Structural
Nerve Tissue Proteins - metabolism
Neurons
Neurons - ultrastructure
P branes
Protein Conformation
Purkinje cells
Rabbits
S100 Proteins - immunology
S100 Proteins - metabolism
Synapses
Synapses - ultrastructure
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Summary:A theory is presented according to which the neuronal membrane and synapses are influenced by membrane-bound S100 protein and a membrane-associated network of actin-like, 20- angstrom -diameter, coiled filaments and the competition by both proteins for Ca2+. The discussion is based on observations made with fluorescein- and peroxidase-conjugated antiserum against S100 protein on isolated nerve cells. A small part of the S100 protein is membrane-bound in a polar localization that develops postnatally. The competition for Ca2+can influence the state of the network filaments which uncoil on binding Ca2+and affect differently the conformational state of synapses and membrane depending on the S100 protein content.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.71.8.2965