Herpes Simplex-Genitalis Virus Nonvirion Antigens and their Implication in Certain Human Cancers: Unconfirmed

The previously reported data on the existence of herpes simplex-genitalis virus nonvirion, neoantigens with distinctive properties, and on the presence of specific antibodies for these neoantigens only in the sera of specially hyperimmunized guinea pigs or of patients with certain types of cancer, c...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1974-08, Vol.71 (8), p.3248-3252
Main Author: Sabin, Albert B.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral - analysis
Antigens
Antigens - isolation & purification
Antigens, Neoplasm - isolation & purification
Antigens, Viral - isolation & purification
Biological Sciences: Medical Sciences
Cancer
Carcinoma, Squamous Cell - immunology
Cell Line
Complement Fixation Tests
Culture Media
Erythrocytes
Female
Guinea Pigs - immunology
Humans
Immune Sera
Kidneys
Laryngeal Neoplasms - immunology
Larynx
Male
Neoplasms - immunology
Neoplasms - microbiology
Reagents
Simplexvirus
Simplexvirus - immunology
Titration
Viruses
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Summary:The previously reported data on the existence of herpes simplex-genitalis virus nonvirion, neoantigens with distinctive properties, and on the presence of specific antibodies for these neoantigens only in the sera of specially hyperimmunized guinea pigs or of patients with certain types of cancer, could not be confirmed. Many factors that could have been responsible for the difference between the originally reported results and those recently obtained were carefully checked and investigated. The assumption that a mixture of two anticomplementary ingredients bound at least as much complement as the more anticomplementary component, and sometimes more, was found to be incorrect for the ingredients used in this work; the reverse was true. Previous failure to observe some of the strict requirements of the complement fixation test could account for some but not all of the unconfirmed previously reported data. Conclusions, based on the unconfirmed data, including those implicating these viruses in the etiology of certain human cancers, are therefore negated.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.71.8.3248