Specific Induction of Erythroleukemia and Myelogenous Leukemia in Sprague-Dawley Rats

The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1982-09, Vol.79 (17), p.5411-5414
Main Authors: Huggins, Charles B., Grand, Lorraine, Ueda, Norifumi
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene - analogs & derivatives
Animals
Blood
Blood donation
Carcinogens
Hematocrit
Leukemia
Leukemia, Experimental - chemically induced
Leukemia, Experimental - physiopathology
Leukemia, Myeloid - chemically induced
Leukemia, Myeloid - physiopathology
Leukocyte Count
Leukocytes
Liver
Methylnitrosourea
Myeloid leukemia
Neoplasia
Rats
Rats, Inbred Strains
Spleen
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Summary:The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythroleukemia in high incidence in the rats, whereas myelogenous leukemia was not produced.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.79.17.5411