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Specific Induction of Erythroleukemia and Myelogenous Leukemia in Sprague-Dawley Rats
The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS 1982-09, Vol.79 (17), p.5411-5414 |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c558t-3c3ad6a45056e68706919f8797cd6d9ebb2d498b4ca2bcc5aa98886d11a16a963 |
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| container_end_page | 5414 |
| container_issue | 17 |
| container_start_page | 5411 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 79 |
| creator | Huggins, Charles B. Grand, Lorraine Ueda, Norifumi |
| description | The experimental induction of leukemias of two sorts by two powerful chemical carcinogens was investigated in rats of a single strain. In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. Conversely, a set of intravenous injections of 7,8,12-trimethylbenz[a]anthracene specifically elicited erythroleukemia in high incidence in the rats, whereas myelogenous leukemia was not produced. |
| doi_str_mv | 10.1073/pnas.79.17.5411 |
| format | article |
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In Sprague-Dawley rats a series of intravenous injections of N-nitroso-N-methylurea selectively elicited myelogenous leukemia in high yields, whereas erythroleukemia was not evoked. 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| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1982-09, Vol.79 (17), p.5411-5414 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_79_17_5411_fulltext |
| source | JSTOR Archival Journals and Primary Sources Collection; PubMed Central |
| subjects | 9,10-Dimethyl-1,2-benzanthracene - analogs & derivatives Animals Blood Blood donation Carcinogens Hematocrit Leukemia Leukemia, Experimental - chemically induced Leukemia, Experimental - physiopathology Leukemia, Myeloid - chemically induced Leukemia, Myeloid - physiopathology Leukocyte Count Leukocytes Liver Methylnitrosourea Myeloid leukemia Neoplasia Rats Rats, Inbred Strains Spleen |
| title | Specific Induction of Erythroleukemia and Myelogenous Leukemia in Sprague-Dawley Rats |
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