Stimulation of Mucosal Mast Cell Growth in Normal and Nude Rat Bone Marrow Cultures

Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lymphocytes. Conditioned media causing a selective proliferation of...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1983-07, Vol.80 (14), p.4499-4503
Main Authors: Haig, David M., McMenamin, Christine, Gunneberg, Christian, Woodbury, Richard, Ellen E. E. Jarrett
Format: Article
Language:English
Subjects:
Animals
Bone marrow
Bone Marrow - physiology
Bone marrow cells
Cell Division
Cell growth
Cells, Cultured
Cellular immunity
Cultured cells
Immunology
Intestinal Mucosa - physiology
Intestine, Small - physiology
Kinetics
Lymph Nodes - immunology
Lymphocytes
Lymphocytes - immunology
Mast cells
Mast Cells - physiology
Peptide Hydrolases - metabolism
Phagocytes
Rats
Rats, Mutant Strains
T lymphocytes
Thymus Gland - physiology
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Summary:Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lymphocytes. Conditioned media causing a selective proliferation of MMC were derived from mesenteric lymph node cells of Nippostrongylus brasiliensis-infected rats restimulated in vitro with specific antigen or from normal or infected rat mesenteric lymph node cells stimulated with concanavalin A. MMC growth factor is not produced by T-cell-depleted mesenteric lymph node cells or by the mesenteric lymph node cells of athymic rats. By contrast, MMC precursors are present in the bone marrow of athymic rats and are normally receptive to the growth factor produced by the lymphocytes of thymus-intact rats. The thymus dependence of MMC hyperplasia is thus based on the requirement of a thymus-independent precursor for a T-cell-derived growth promoter.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.80.14.4499