Assignment of the Human and Mouse Prion Protein Genes to Homologous Chromosomes

Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-10, Vol.83 (19), p.7358-7362
Main Authors: Sparkes, Robert S., Simon, Melvin, Cohn, Vivian H., Fournier, R. E. K., Lem, Janice, Klisak, Ivana, Heinzmann, Camilla, Blatt, Cila, Lucero, Michael, Mohandas, T., DeArmond, Stephen J., Westaway, David, Prusiner, Stanley B., Weiner, Leslie P.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 20
Complementary DNA
DNA
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Human chromosomes
Humans
Hybridity
Mice
Microcell hybrids
Molecular and cellular biology
Molecular genetics
Prions
Prions - genetics
Somatic cells
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purified preparations of scrapie prions contain one major macromolecule, designated prion protein (PrP). Genes encoding PrP are found in normal animals and humans but not within the infectious particles. The PrP gene was assigned to human chromosome 20 and the corresponding mouse chromosome 2 using somatic cell hybrids. In situ hybridization studies mapped the human PrP gene to band 20p12→ pter. Our results should lead to studies of genetic loci syntenic with the PrP gene, which may play a role in the pathogenesis of prion diseases or other degenerative neurologic disorders.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.19.7358