A Drosophila Mutation that Eliminates a Calcium-Dependent Potassium Current

A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+currents remain normal, providing evidence that ICis mediated by a molecularly distinguishable set of channels. The pharmacological propert...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-11, Vol.83 (21), p.8415-8419
Main Authors: Elkins, Thomas, Ganetzky, Barry, Wu, Chun-Fang
Format: Article
Language:English
Subjects:
4-Aminopyridine
Action Potentials
Aminopyridines - pharmacology
Animal genetics
Animals
Biological and medical sciences
Calcium - physiology
Cell physiology
Cylinders
Drosophila
Electric current
Electric potential
Electrodes
Female
Flight muscles
Fundamental and applied biological sciences. Psychology
Genetic mutation
Ion Channels - physiology
Molecular and cellular biology
Muscles - physiology
Mutation
Neurons
Neurotransmission
Potassium - metabolism
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Summary:A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+currents remain normal, providing evidence that ICis mediated by a molecularly distinguishable set of channels. The pharmacological properties of ICare similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that ICplays the major role in its repolarization.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.21.8415