A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include A...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1991-01, Vol.88 (2), p.557-560
Main Authors: Delgado, R. (Universidad de Chile, Santiago, Chile), Hidalgo, P, Diaz, F, Latorre, R, Labarca, P
Format: Article
Language:English
Subjects:
8-Bromo Cyclic Adenosine Monophosphate - pharmacology
ADENOSINE MONOPHOSPHATE
ADENOSINMONOFOSFATO
Animals
Behavioral neuroscience
Biochemistry. Physiology. Immunology
Biological and medical sciences
Cyclic AMP - pharmacology
Cyclic AMP - physiology
Cyclic GMP - pharmacology
DROSOPHILA
Drosophila - genetics
Drosophila - physiology
Electric potential
Fractions
Fundamental and applied biological sciences. Psychology
Genetic mutation
Insecta
Invertebrates
ION
IONES
Larva
Larvae
LARVAS
LARVE
Male animals
Membrane potential
Membrane Potentials - drug effects
MUSCLE
Muscles - physiology
MUSCULOS
MUTANT
MUTANTES
Mutation
Neurobiology
NEUROFISIOLOGIA
NEUROPHYSIOLOGIE
Neuroscience
Physiology. Development
POTASIO
POTASSIUM
Potassium Channels - drug effects
Potassium Channels - genetics
Potassium Channels - physiology
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Summary:Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.2.557