Induction of Host Signal Transduction Pathways by Helicobacter pylori

Adherence of Helicobacter pylori to cultured gastric epithelial cells is associated with several cellular events, including the tyrosine phosphorylation of a 145-kDa host protein; the reorganization of the host cell actin and associated cellular proteins, like vasodilator-stimulated phosphoprotein,...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-07, Vol.94 (14), p.7595-7599
Main Authors: Segal, Ellyn D., Lange, C., Covacci, A., Tompkins, L. S., Falkow, S.
Format: Article
Language:English
Subjects:
Actins
Bacteria
Biological Sciences
Cell Line
Cell lines
Cells
Cellular biology
Cultured cells
Digestive system diseases
Epithelial cells
Epithelium - metabolism
Epithelium - microbiology
Epithelium - pathology
Gastric Mucosa - metabolism
Helicobacter pylori
Helicobacter pylori - physiology
Humans
Infections
Interleukin-8 - metabolism
Microbiology
Mutation
Phosphorylation
Secretion
Signal Transduction
Stomach
Stomach - microbiology
Stomach - pathology
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Summary:Adherence of Helicobacter pylori to cultured gastric epithelial cells is associated with several cellular events, including the tyrosine phosphorylation of a 145-kDa host protein; the reorganization of the host cell actin and associated cellular proteins, like vasodilator-stimulated phosphoprotein, adjacent to the attached bacterial cell; and the subsequent release of the cytokine, interleukin 8 (IL-8). H. pylori isolated from patients with ulcer disease and gastric cancer contain a DNA insertion, the cag pathogenicity island (PAI), that is not present in bacteria isolated from individuals with asymptomatic infection. Mutations in a number of PAI genes abolish tyrosine phosphorylation and IL-8 synthesis but not the cytoskeletal rearrangements. Kinase inhibition studies suggest there are two distinct pathways operative in stimulating IL-8 release from host cells and one of these H. pylori pathways is independent of the tyrosine phosphorylation step.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.14.7595