Epithelial Antibiotic Induced in States of Disease

Epithelial defensins provide an active defense against the external microbial environment. We investigated the distribution and expression of this class of antimicrobial peptides in normal cattle and in animals in varying states of disease. β -defensin mRNA was found to be widely expressed in numero...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-08, Vol.94 (16), p.8686-8690
Main Authors: Stolzenberg, Ethan D., Anderson, G. Mark, Ackermann, Mark R., Whitlock, Robert H., Zasloff, Michael
Format: Article
Language:English
Subjects:
Animals
Antimicrobials
Biochemistry
Biological Sciences
Blood Proteins - biosynthesis
Bronchi - metabolism
Bronchi - microbiology
Bronchi - physiopathology
Cattle
Chronic diseases
Defensins
Epithelial cells
Epithelium
Epithelium - metabolism
Epithelium - microbiology
Epithelium - physiopathology
Immunity (Disease)
In Situ Hybridization
Infections
Intestinal Mucosa - metabolism
Intestinal Mucosa - microbiology
Intestinal Mucosa - physiopathology
Mannheimia haemolytica
Mycobacterium avium subsp. paratuberculosis
Mycobacterium paratuberculosis
Neutrophils
Paratuberculosis
Paratuberculosis - metabolism
Paratuberculosis - physiopathology
Pasteurella haemolytica
Pasteurella Infections - metabolism
Pasteurella Infections - physiopathology
Peptides
RNA
Ungulates
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Summary:Epithelial defensins provide an active defense against the external microbial environment. We investigated the distribution and expression of this class of antimicrobial peptides in normal cattle and in animals in varying states of disease. β -defensin mRNA was found to be widely expressed in numerous exposed epithelia but was found at higher levels in tissues that are constantly exposed to and colonized by microorganisms. We observed induction in ileal mucosa during chronic infection with Mycobacterium paratuberculosis and in bronchial epithelium after acute infection with Pasteurella haemolytica. It has been proposed that expression of antimicrobial peptides is an integral component of the inflammatory response. The results reported here support this hypothesis and suggest that epithelial defensins provide a rapidly mobilized local defense against infectious organisms.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.16.8686