A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway

Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (19), p.10467-10472
Main Authors: Williams, R.W, Wilson, J.M, Meyerowitz, E.M
Format: Article
Language:English
Subjects:
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Alleles
Amino acids
APICAL MERISTEMS
Arabidopsis
Arabidopsis - enzymology
Arabidopsis Proteins
ARABIDOPSIS THALIANA
ARN MENSAJERO
ARN MESSAGER
AUTOPHOSPHORYLATION
Biological Sciences
Botany
Carpels
Enzymes
ENZYMIC ACTIVITY
ESTERASAS
ESTERASE
ESTERASES
EXPRESION GENICA
EXPRESSION DES GENES
FLEUR
FLORES
FLOWERS
FOSFORILACION
GENE
GENE EXPRESSION
Gene Expression Regulation, Plant
GENES
INFLORESCENCE MERISTEMS
KAPP GENE
MERISTEMAS
MERISTEMAS APICALES
MERISTEME
MERISTEME APICAL
MERISTEMS
MESSENGER RNA
Phenotypes
Phosphatases
PHOSPHOPROTEIN PHOSPHATASE
Phosphoprotein Phosphatases - genetics
Phosphoprotein Phosphatases - metabolism
PHOSPHORYLATION
PLANTAS TRANSGENICAS
PLANTE TRANSGENIQUE
Plants
Plants, Genetically Modified
Protein Binding
PROTEIN KINASE
PROTEINA QUINASA
PROTEINE KINASE
Regulator genes
RNA
RNA, Messenger - genetics
Signal Transduction
STRUCTURAL GENES
TRANSGENIC PLANTS
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Summary:Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying molecular mechanisms controlling cell proliferation and differentiation in these structures. We have shown previously that the CLAVATA1 (CLV1) gene in Arabidopsis encodes a receptor kinase-like protein that controls the size of the apical and floral meristems. Here, we show that KAPP, a gene encoding a kinase-associated protein phosphatase, is expressed in apical and young floral meristems, along with CLV1. Overexpression of KAPP mimics the clv1 mutant phenotype. Furthermore, CLV1 has kinase activity: it phosphorylates both itself and KAPP. Finally, KAPP binds and dephosphorylates CLV1. We present a model where KAPP functions as a negative regulator of the CLAVATA1 signal transduction pathway
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.19.10467